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Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe): an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlled trial in Belgium and the Netherlands

Julia L.M. Bels; Steven Thiessen; Rob J.J. van Gassel; A. Beishuizen; Ashley de Bie Dekker; Vincent Fraipont; Stoffel Lamote; Didier Ledoux; Clarissa Scheeren; Elisabeth de Waele; Arthur R.H. van Zanten; Laura Bormans-Russell; Bas C.T. van Bussel; Marlies M.J. Dictus; Tom Fivez; Ingeborg Harks; Iwan C.C. van der Horst; Joop Jonckheer; Hugues Marechal; Paul B. Massion; Ingrid Meex; Michelle C. Paulus; Martin Rinket; Susanne van Santen; Katrien Tartaglia; Adam M. Deane; Frieda Demuydt; Zudin Puthucheary; Lilian Vloet; P.J.M. Weijs; Sander M.J. van Kuijk; Marcel C.G. van de Poll; Dieter Mesotten

Increased protein provision might ameliorate muscle wasting and improve long-term outcomes in critically ill patients. The aim of the PRECISe trial was to assess whether higher enteral protein provision (ie, 2·0 g/kg per day) would improve health-related quality of life and functional outcomes in critically …

2024-08-17GezondheidArtikel

Metabolic load during morning care and active bed exercises in critically ill patients

Kwakman, Robin C.H. (Faculteit Gezondheid); Voorn, Eric L.; Sommers, Juultje; Gerrits, Karin; Nollet, Frans; Engelbert, Raoul H.H. (Lectoraat Fysiotherapie - Transitie Van Zorg Bij Complexe Patiënten); van der Schaaf, Marike (Lectoraat Revalidatie In De Acute Zorg)

Background: To avoid overexertion in critically ill patients, information on the physical demand, i.e., metabolic load, of daily care and active exercises is warranted. Objective: The objective of this study was toassess the metabolic load during morning care activities and active bed exercises in mechanically …

2024-05AlgemeenArtikel

Open Versus Closed Suctioning in Invasively Ventilated Critically Ill Patients for Sustainability of ICU Care: A Life-Cycle Assessment Comparison

Stilma, Willemke (Centre Of Expertise Urban Vitality); Esmeijer, Andrea; Paulus, Frederique (Lectoraat Critical Care); Frenzel, Tim; Touw, Hugo; Stobernack, Tim

2024-02AlgemeenArtikel

Airway Mucus in Invasively Ventilated Critically Ill Patients

Stilma, Willemke (Faculteit Gezondheid); Lilien, Thijs A; Bos, Lieuwe DJ; Saatpoor, Aryen; Elsayed, Omar; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J; Bem, Reinout A; Linssen, Rosalie SN

Patients who are critically ill and receiving invasivemechanical ventilation are at increased risk for accumula-tion of secretions in the lower airways. Such accumula-tion of airway mucus can induce atelectasis and contributeto ventilator-associated pneumonia. Preventive airwaycare interventions, including …

2023-09-01AlgemeenArtikel

Differences in Ventilation Management and Outcomes between the Two First Waves of the COVID-19 Pandemic—A Comparison between Two Nationwide Observational Studies in The Netherlands

The aim of this analysis was to compare ventilation management and outcomes in invasively ventilated patients with acute hypoxemic respiratory failure due to coronavirus disease 2019 (COVID-19) between the first and second wave in the Netherlands. This is a post hoc analysis of two nationwide observational …

2023-07-05AlgemeenArtikel

The impact of high versus standard enteral protein provision on functional recovery following intensive care admission (PRECISE trial): study protocol for a randomized controlled, quadruple blinded, multicenter, parallel group trial in mechanically ventilated patients

Rob J.J. van Gassel (Onderzoeker); Julia L.M. Bels (Onderzoeker); Katrien Tartaglia (Onderzoeker); Bas C.T. Bussel (Onderzoeker); Sander M.J. van Kuijk (Onderzoeker); Adam M. Deane (Onderzoeker); Zudin Puthucheary (Onderzoeker); Peter Weijs (Onderzoeker); Lilian Vloet (Lector); Bert (A.) Beishuizen (Onderzoeker); Ashley de Bie Dekker (Onderzoeker); Vincent Fraipont (Onderzoeker); Stoffel Lamote (Onderzoeker); Didier Ledoux (Onderzoeker); Clarissa Scheeren (Onderzoeker); Elisabeth de Waele (Onderzoeker); Arthur R.H. van Zanten (Onderzoeker); Dieter Mesotten (Onderzoeker); Marcel C.G. van de Poll (Onderzoeker)

Critically ill patients are subject to severe skeletal muscle wasting during intensive care unit (ICU) stay, resulting in impaired short- and long-term functional outcomes and health-related quality of life. Increased protein provision may improve functional outcomes in ICU patients by attenuating skeletal …

2023-06-19GezondheidArtikel

Lung Ultrasound to Determine the Effect of Lower vs. Higher PEEP on Lung Aeration in Patients without ARDS—A Substudy of a Randomized Clinical Trial

Zimatore, Claudio; Algera, Anna Geke; Botta, Michela; Pierrakos, Charalampos; Serpa Neto, Ary; Grasso, Salvatore; Schultz, Marcus J.; Pisani, Luigi; Paulus, Frederique (Lectoraat Critical Care)

Background: Ventilation with lower positive end–expiratory pressure (PEEP) may cause loss of lung aeration in critically ill invasively ventilated patients. This study investigated whether a systematic lung ultrasound (LUS) scoring system can detect such changes in lung aeration in a study comparing …

2023-06AlgemeenArtikel

Oxygen Consumption with High-Flow Nasal Oxygen versus Mechanical Ventilation—An International Multicenter Observational Study in COVID–19 Patients (PROXY–COVID)

Botta, Michela; Caritg, Oriol; van Meenen, David M.P.; Pacheco, Andrés; Tsonas, Anissa M.; Mooij, Willemijn E.; Burgener, Alessia; Hehl, Tosca Manrique; Shrestha, Gentle S.; Horn, Janneke; Tuinman, Pieter R.; Paulus, Frederique (Lectoraat Critical Care); Roca, Oriol; Schultz, Marcus J.

The COVID–19 pandemic led to local oxygen shortages worldwide. To gain a better understanding of oxygen consumption with different respiratory supportive therapies, we conducted an international multicenter observational study to determine the precise amount of oxygen consumption with high-flow nasal …

2023-05AlgemeenArtikel

Effect of mechanical power on mortality in invasively ventilated ICU patients without the acute respiratory distress syndrome

van Meenen, David M.P.; Algera, Anna Geke; Schuijt, Michiel T.U.; Simonis, Fabienne D.; van der Hoeven, Sophia M.; Neto, Ary Serpa; Abreu, Marcelo Gama de; Pelosi, Paolo; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J.

BACKGROUND The mechanical power of ventilation (MP) has an association with outcome in invasively ventilated patients with the acute respiratory distress syndrome (ARDS). Whether a similar association exists in invasively ventilated patients without ARDS is less certain. OBJECTIVE To investigate the …

2023-01AlgemeenArtikel

Mechanical insufflation-exsufflation for invasively ventilated critically ill patients

Stilma, Willemke (Faculteit Gezondheid); Verweij, Lotte; Spek, Bea; Scholte Op Reimer, Wilhelmina Johanna Maria; Schultz, Marcus Josephus; Paulus, Frederique (Lectoraat Critical Care); Rose, Louise

INTRODUCTION: Mechanical Insufflation-Exsufflation (MI-E) is used as an airway clearance intervention in primary care (home ventilation), long-term care (prolonged rehabilitation after intensive care, neuromuscular diseases, and spinal cord injury), and increasingly in acute care in intensive care units …

2023AlgemeenArtikel

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