Background: Experienced assessors show good intra-rater reproducibility (within-session and between-session agreement and reliability) when using an algometer to determine pressure pain thresholds (PPT). However, it is unknown whether novice assessors perform equally well. This study aimed to determine …

Advances in neuroscience and the identification of the new concept of central sensitisation (CS) have increased understanding of the complexity of pain, offered explanations for pain without a source and reasons for its persistence, forcing a more holistic chronic pain (CP) treatment approach. Pain neuroscience …

Conservative, surgical and pharmacological strategies for chronic low back pain (CLBP) management offer at best modest effect sizes in reducing pain and related disability, indicating a need for improvement. Such improvement may be derived from applying contemporary pain neuroscience to the management …

Aan de hand van deze literatuurstudie worden de symptomen van centrale sensitisatie bij fibromalgiepatiënten in kaart gebracht en er wordt bepaald of deze kenmerkend zijn voor centrale sensitisatie bij deze patiëntengroep. Hiervoor moeten ze door minstens twee RCT's of CT's bevestigd worden. Daarnaast …

Background: Drug resistance is a major problem in ovarian cancer. Triggering apoptosis using death ligands such as tumour necrosis factor-related apoptosis inducing ligand (TRAIL) might overcome chemoresistance. Methods: We investigated whether acquired cisplatin resistance affects sensitivity to recombinant …