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Airway Mucus in Invasively Ventilated Critically Ill Patients

Stilma, Willemke (Faculteit Gezondheid); Lilien, Thijs A; Bos, Lieuwe DJ; Saatpoor, Aryen; Elsayed, Omar; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J; Bem, Reinout A; Linssen, Rosalie SN

Patients who are critically ill and receiving invasivemechanical ventilation are at increased risk for accumula-tion of secretions in the lower airways. Such accumula-tion of airway mucus can induce atelectasis and contributeto ventilator-associated pneumonia. Preventive airwaycare interventions, including …

2023-09-01AlgemeenArtikel

The Use of Mechanical Insufflation-Exsufflation in Invasively Ventilated Critically Ill Adults

Swingwood, Ema L; Stilma, Willemke (Faculteit Gezondheid); Tume, Lyvonne N; Cramp, Fiona; Voss, Sarah; Bewley, Jeremy; Ntoumenopoulos, George; Schultz, Marcus J; Scholte Op Reimer, Wilma; Paulus, Frederique (Lectoraat Critical Care); Rose, Louise

Mechanical insufflation-exsufflation (MI-E) is traditionally used in the neuromuscular population. There is growing interest of MI-E use in invasively ventilated critically ill adults. We aimed to map current evidence on MI-E use in invasively ventilated critically ill adults. Two authors independently …

2022-08-01AlgemeenAndersoortig materiaal

Repeated-Dose Toxicity, Biodistribution, and Shedding Assessments With a ChAd155 Respiratory Syncytial Virus Vaccine Candidate Evaluated in Rabbits and Rats

AH Stokes; C Planty; J Pion; P Ancian; A Rogue; C Bansard; J Silvano; D Papineau; N Ben Abdeljelil; G Maruggi; HF Song; C Spickler; K Blouin; G Dubois; LA Rodriguez; J Baumeister; AM Steff; E Destexhe

Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections (LRTI) in infants, and toddlers and vaccines are not yet available. A pediatric RSV vaccine (ChAd155-RSV) is being developed to protect infants against RSV disease. The ChAd155-RSV vaccine consists of a recombinant …

2022AlgemeenArtikel

Airway Care Interventions for Invasively Ventilated Critically Ill Adults-A Dutch National Survey

Stilma, Willemke (Faculteit Gezondheid); van der Hoeven, Sophia M.; Scholte op Reimer, Wilma J. M.; Schultz, Marcus J.; Rose, Louise; Paulus, Frederique (Centre Of Expertise Urban Vitality)

Airway care interventions may prevent accumulation of airway secretions and promote their evacuation, but evidence is scarce. Interventions include heated humidification, nebulization of mucolytics and/or bronchodilators, manual hyperinflation and use of mechanical insufflation-exsufflation (MI-E). Our …

2021-08AlgemeenArtikel

Chest physiotherapy compared to no chest physiotherapy for cystic fibrosis

Warnock, L.; Gates, A.; van der Schans, Cees (Healthy Ageing, Allied Health Care And Nursing)

BACKGROUND: Chest physiotherapy is widely used in people with cystic fibrosis in order to clear mucus from the airways. OBJECTIVES: To determine the effectiveness and acceptability of chest physiotherapy compared to no treatment or spontaneous cough alone to improve mucus clearance in cystic fibrosis. …

2013AlgemeenArtikel

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis

Elkins, M R; Jones, A; van der Schans, Cees (Healthy Ageing, Allied Health Care And Nursing)

BACKGROUND: Chest physiotherapy is widely prescribed to assist the clearance of airway secretions in people with cystic fibrosis (CF). Positive expiratory pressure (PEP) devices provide constant back pressure to the airways during expiration. This may improve clearance by building up gas behind mucus …

2006-04-19AlgemeenArtikel

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis

Main, E; Prasad, A; van der Schans, Cees (Healthy Ageing, Allied Health Care And Nursing)

BACKGROUND: Cystic fibrosis is an inherited life-limiting disorder, characterised by pulmonary infections and thick airway secretions. Chest physiotherapy has been integral to clinical management in facilitating removal of airway secretions. Conventional chest physiotherapy techniques (CCPT) have depended …

2005-01-24AlgemeenArtikel

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