Background and aims: Observational data indicate that diets rich in fruits and vegetables have a positive effect on inflammatory status, improve metabolic resilience and may protect against the development of non-communicable diseases. Nevertheless, experimental evidence demonstrating a causal relationship …

The closing of schools and sports clubs during theCOVID-19 lockdown raised questions about thepossible impact on children’s motor skilldevelopment. Therefore we compared motorcompetence development over a one-year periodamong four different cohorts of primary schoolchildren. A total of 992 children from …

Background The closing of schools and sports clubs during the COVID-19 lockdown raised questions about the possible impact on children’s motor skill development. Therefore, we compared motor skill development over a one-year period among four different cohorts of primary school children of which two …

BACKGROUND: Physical activity may be both a risk and protective factor for falls and fall-related fractures. Despite its positive effects on muscle and bone health, physical activity also increases exposure to situations where falls and fractures occur. This paradox could possibly be explained by frailty …

Ubiquitin (Ub) is a protein which post-translationally modifies other proteins (its target substrates) and determines their cellular fate. Ub can label substrates for degradation, it can also alter the location of their substrates within a cell or even affect their activity. Chains can be formed via …

Using an online questionnaire among 516 Dutch parents (children between 1 and 12 years; 68% mothers, 18% single parents) this study explored whether parents see media devices as useful tools in childrearing, and how parent-family characteristics and parental perceptions on parenting, media effects and …

Epidemiological miner cohort data used to estimate lung cancer risks related to occupational radon exposure often lack cohort-wide information on exposure to tobacco smoke, a potential confounder and important effect modifier. We have developed a method to project data on smoking habits from a case-control …

A substantial proportion of chronic disease patients do not respond to self-management interventions, which suggests that one size interventions do not fit all, demanding more tailored interventions. To compose more individualized strategies, we aim to increase our understanding of characteristics associated …