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The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration

Ortí-Casañ, N.; Boerema, A.S. (Lid Lectoraat); Köpke, K.; Ebskamp, A.; Keijser, J.; Zhang, Y.; Chen, T.; Dolga, A.M.; Broersen, K.; Fischer, R.; Pfizenmaier, K.; Kontermann, R.E.; Eisel, U.L.M.

Tumor necrosis factor alpha (TNF-α) and its key role in modulating immune responses has been widely recognized as a therapeutic target for inflammatory and neurodegenerative diseases. Even though inhibition of TNF-α is beneficial for the treatment of certain inflammatory diseases, total neutralization …

2023-06-30GezondheidArtikel

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Jaap Buitink; Jan Ebskamp

2019-02AlgemeenBoek

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The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration

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