We introduce two novel methods for multivariate genome-wide-association meta-analysis (GWAMA) of related traits that correct for sample overlap. A broad range of simulation scenarios supports the added value of our multivariate methods relative to univariate GWAMA. We applied the novel methods to life …

BACKGROUND & AIMS: Lower birth weight is associated with an increased risk of cardiovascular and metabolic disease. These associations may, at least in part, be explained by alterations in dietary intake in later life. The aim of this study is to examine whether lower birth weight is associated with …

"Hoogbegaafde leerlingen verliezen nog weleens hun motivatie binnen het basisonderwijs. Een reden hiervoor kan zijn dat de leerling te weinig uitdaging krijgt binnen de reguliere lessen. In dit actieonderzoek wordt met behulp van de literatuur en praktijk onderzocht of de motivatie van de leerlingen …