Background: In the Netherlands, general practitioners (GPs) play a key role in provider-initiated HIV testing, but opportunities for timely diagnosis are regularly missed. We implemented an educational intervention to improve HIV testing by GPs from 2015 to 2020, and observed a 7% increase in testing …

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitochondrial dysfunction is thought to be a key driver of …

Lyme borreliosis, commonly known as Lyme disease, is a vector-borne disease that is caused by the bacterium Borrelia burgdorferi sensu lato. Infected ticks can transmit this disease and infect humans. Decreasing human Lyme infections could be achieved by vegetation control , since mortality and questing …

Agent-based models (ABMs) are important tools for predicting infectious disease epidemics and for designing effective interventions. ABMs take into account individual differences, for instance in contact rate. The drawbacks of ABMs are high complexity and low performance. In this paper, we present a …