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Zocht je misschien: aerial, arrival?

Effect of lung ultrasound-guided fluid deresuscitation on duration of ventilation in intensive care unit patients (CONFIDENCE)

Blok, Siebe G.; Mousa, Amne; Brouwer, Michelle G.; de Grooth, Harm-Jan; Neto, Ary Serpa; Blans, Michiel J.; den Boer, Sylvia; Dormans, Tom; Endeman, Henrik; Roeleveld, Timo; Scholten, Harm; van Slobbe-Bijlsma, Eline R.; Scholten, Erik; Touw, Hugo; van der Ven, Fleur Stefanie L. I. M.; Wils, Evert-Jan; van Westerloo, David J.; Heunks, Leo M. A.; Schultz, Marcus J.; Paulus, Frederique (Lectoraat Critical Care); Tuinman, Pieter R.

Background Fluid therapy is a common intervention in critically ill patients. It is increasingly recognised that deresuscitation is an essential part of fluid therapy and delayed deresuscitation is associated with longer invasive ventilation and length of intensive care unit (ICU) stay. However, optimal …

2023AlgemeenArtikel

Effect of muscle alteration on long term survival in ischemic stroke patients

Akshay Biere (Student); Martijn Scheffer (Student); Patrick Schenkers (Begeleider); Peter Lesterhuis (Begeleider)

Patients who had an ischemic stroke have a poor life expectancy. To improve prognosis in ischemic stroke it is needed to discover additional prognostic biomarkers. This study investigated whether sarcopenia or myosteatosis affected long-term survival in ischemic stroke patients. The secondary aim was …

2020-01-30GezondheidBachelor

The diagnostic accuracy of clinical examination for estimating cardiac index in critically ill patients

SICS Study Group

PURPOSE: Clinical examination is often the first step to diagnose shock and estimate cardiac index. In the Simple Intensive Care Studies-I, we assessed the association and diagnostic performance of clinical signs for estimation of cardiac index in critically ill patients. METHODS: In this prospective, …

2019-02-27AlgemeenArtikel

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

Heeres, André (Biobased Ingredients And Materials); Xu, Hu; van Marion, Denise MS; Hoogstra-Berends, Femke; Zhang, Deli; Seerden, Jean-Paul; Loen, Lizette; Steen, Herman; Henning, Robert H; Brundel, Bianca J J M

Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems. Clinical application of GGA in AF is limited, due to low systemic concentrations owing to the hydrophobic character …

2019-01-18AlgemeenArtikel

Acute and chronic diseases as part of multimorbidity in acutely hospitalized older patients

Buurman, Bianca M.; Frenkel, Wijnanda J.; Abu-Hanna, Ameen; Parlevliet, Juliette L.; de Rooij, Sophia E.

Background To describe the prevalence of multimorbidity and to study the association between acute and chronic diseases in acutely hospitalized older patients Methods Prospective cohort study conducted between 2006 and 2008 in three teaching hospitals in the Netherlands. 639 patients aged 65 years and …

2016-01AlgemeenArtikel

Hydroximic acid derivatives

Crul, Tim; Toth, Noemi; Piotto, Stefano; Literati-Nagy, Peter; Tory, Kalman; Haldimann, Pierre; Kalmar, Bernadett; Greensmith, Linda; Torok, Zsolt; Balogh, Gabor; Gombos, Imre; Campana, Federica; Concilio, Simona; Gallyas, Ferenc; Nagy, Gabor; Berente, Zoltan; Gungor, Burcin; Peter, Maria; Glatz, Attila; Hunya, Akos; Literati-Nagy, Zsuzsanna; Vigh, Laszlo; Hoogstra-Berends, Femke; Heeres, André (Biobased Ingredients And Materials); Kuipers, Irma; Loen, Lizette; Seerden, Jean-Paul; Zhang, Deli; Meijering, Roelien A M; Henning, Robert H; Brundel, Bianca J J M; Kampinga, Harm H; Koranyi, Laszlo; Szilvassy, Zoltan; Mandl, Jozsef; Sumegi, Balazs; Febbraio, Mark A; Horvath, Ibolya; Hooper, Philip L; Vigh, Laszlo

According to the "membrane sensor" hypothesis, the membrane's physical properties and microdomain organization play an initiating role in the heat shock response. Clinical conditions such as cancer, diabetes and neurodegenerative diseases are all coupled with specific changes in the physical state and …

2013AlgemeenArtikel

Heat shock protein-inducing compounds as therapeutics to restore proteostasis in atrial fibrillation

Hoogstra-Berends, Femke; Meijering, Roelien A M; Zhang, Deli; Heeres, André (Biobased Ingredients And Materials); Loen, Lizette; Seerden, Jean-Paul; Kuipers, Irma; Kampinga, Harm H; Henning, Robert H; Brundel, Bianca J J M

Atrial fibrillation (AF) is the most common clinical tachyarrhythmia associated with significant morbidity and mortality and is expected to affect approximately 30 million North Americans and Europeans by 2050. AF is a persistent disease, caused by progressive, often age-related, derailment of proteostasis …

2012-04-01AlgemeenArtikel

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