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The impact of anatomical changes during photon or proton based radiation treatment on tumor dose in glioblastoma dose escalation trials

Eline Hessen; Sebastian Makocki; Uulke A. van der Heide; Bas Jasperse; Lotte Lutkenhaus; Emmy Lamers (Lid Lectoraat); Eugene Damen; Esther G.C. Troost; Gerben R. Borst

Purpose/Objective: Most dose-escalation trials in glioblastoma patients integrate the escalated dose throughout the standard course by targeting a specific subvolume. We hypothesize that anatomical changes during irradiation may affect the dose coverage of this subvolume for both proton- and photon-based …

2021-09-28GezondheidArtikel

Characterization of automatic treatment planning approaches in radiotherapy

Geert Wortel; Dave Eekhout; Emmy Lamers (Lid Lectoraat); René van der Bel; Karen Kiers; Terry Wiersma; Tomas Janssen; Eugene Damen

Background and purpose: Automatic approaches are widely implemented to automate dose optimization in radiotherapy treatment planning. This study systematically investigates how to configure automatic planning in order to create the best possible plans. Materials and methods: Automatic plans were generated …

2021-07-13GezondheidArtikel

Accuracy of an MR‑only workflow for prostate radiotherapy using semi‑automatically burned‑in fiducial markers

Karin Goudschaal; F. Beeksma; M. Boon; M. Bijveld; J. Visser; K. Hinnen; Z. van Kesteren

Abstract Background: The benefit of MR-only workflow compared to current CT-based workflow for prostate radiotherapy is reduction of systematic errors in the radiotherapy chain by 2–3 mm. Nowadays, MRI is used for target delineation while CT is needed for position verification. In MR-only workflows, …

2021-02-22GezondheidArtikel

Development and validation of a patient decision aid for prostate Cancer therapy

Anshu Ankolekar; Ben G. L. Vanneste; Esther Bloemen-van Gurp (Lid Lectoraat); Joep G. van Roermund; Evert J. van Limbergen; Kees van de Beek; Tom Marcelissen; Victor Zambon; Matthias Oelke; Andre Dekker; Cheryl Roumen; Philippe Lambin (Docent); Adriana Berlanga; Rianne Fijten

Background: Patient decision aids (PDAs) can support the treatment decision making process and empower patients to take a proactive role in their treatment pathway while using a shared decision-making (SDM) approach making participatory medicine possible. The aim of this study was to develop a PDA for …

2019-01-01GezondheidArtikel

Post-mortem fluid stasis in the sinus,trachea and mainstem bronchi

Stephanie Biljardt (Student); Renee Tijhuis (Student); Anne Brummel (Student); T. Sieswerda-Hoogendoorn; L.F.M. Beenen; R.R. van Rijn

Introduction: The purposeofthisstudywastoassessoccurrenceof fluid stasisinthesinus,trachea and mainstem bronchionPMCT. Materials andmethods: Patients were collected from different groups, two adult and two paediatric groups. Patients who died from drowning or evident trauma to head and neck were excluded …

2015-07-09GezondheidArtikel

Multicriteria optimization enables less experienced planners to efficiently produce high quality treatment plans in head and neck cancer radiotherapy

Kierkels, Roel G J; Visser, Ruurd; Bijl, Hendrik P; Langendijk, Johannes A; van 't Veld, Aart A; Steenbakkers, Roel J H M; Korevaar, Erik W

OBJECTIVES: To demonstrate that novice dosimetry planners efficiently create clinically acceptable IMRT plans for head and neck cancer (HNC) patients using a commercially available multicriteria optimization (MCO) system. METHODS: Twenty HNC patients were enrolled in this in-silico comparative planning …

2015-04-12AlgemeenArtikel

Evaluation of DVH-based treatment plan verification in addition to gamma passing rates for head and neck IMRT

Visser, Ruurd; Wauben, David J.L.; de Groot, Martijn; Steenbakkers, Roel J.H.M.; Godart, Jeremy; van 't Veld, Aart A.; Langendijk, Johannes A.; Korevaar, Erik W.; Bijl, Hendrik P

Background and purpose: Treatment plan verification of intensity modulated radiotherapy (IMRT) is generally performed with the gamma index (GI) evaluation method, which is difficult to extrapolate to clinical implications. Incorporating Dose Volume Histogram (DVH) information can compensate for this. …

2014-09-01AlgemeenArtikel

The impact of gastrointestinal and genitourinary toxicity on health related quality of life among irradiated prostate cancer patients

Schaake, Wouter (Healthy Ageing, Allied Health Care And Nursing); Wiegman, Erwin M.; de Groot, Martijn; van der Laan, Hans Paul; van der Schans, Cees (Healthy Ageing, Allied Health Care And Nursing); van den Bergh, Alfons C.M.; Langendijk, Johannes A.

PURPOSE: To determine the impact of late radiation-induced toxicity on health-related quality of life (HRQoL) among patients with prostate cancer. PATIENTS AND METHODS: The study sample was composed of 227 patients, treated with external beam radiotherapy. Common Terminology Criteria for Adverse Events …

2014-02-01AlgemeenArtikel

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