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Dietary Supplementation with Nondigestible Oligosaccharides Reduces Allergic Symptoms and Supports Low Dose Oral Immunotherapy in a Peanut Allergy Mouse Model

Laura Wagenaar (Onderzoeker); Marianne Bol-Schoenmakers (Onderzoeker); Giulio Giustarini (Onderzoeker); Marlotte M. Vonk (Onderzoeker); Betty C.A.M. van Esch (Onderzoeker); Léon M.J. Knippels (Onderzoeker); Johan Garssen (Onderzoeker); Joost Smit (Onderzoeker); Raymond Pieters (Lector)

Abstract 1 Scope A major downside of oral immunotherapy (OIT) for food allergy is the risk of severe side effects. Non‐digestible short‐ and long‐chain fructo‐oligosaccharides (scFOS/lcFOS) reduce allergy development in murine models. Therefore, it is hypothesized that scFOS/lcFOS can also support …

2018-08-13GezondheidArtikel

The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models

Marlotte M. Vonk (Onderzoeker); Laura Wagenaar (Onderzoeker); Raymond Pieters (Lector); Léon M.J. Knippels (Onderzoeker); L.E.M. Willemsen (Onderzoeker); J.J. Smit (Onderzoeker); BCAM van Esch (Onderzoeker); J. Garssen (Onderzoeker)

From Pubmed: " BACKGROUND: Antigen-specific immunotherapy (AIT) is a promising therapeutic approach for both cow's milk allergy (CMA) and peanut allergy (PNA), but needs optimization in terms of efficacy and safety. AIM: Compare oral immunotherapy (OIT) and subcutaneous immunotherapy (SCIT) in …

2017GezondheidArtikel

Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model

Marlotte M. Vonk (Onderzoeker); Mara A.P. Diks (Onderzoeker); Laura Wagenaar (Onderzoeker); J.J. Smit (Onderzoeker); Raymond Pieters (Lector); Johan Garssen (Onderzoeker); Betty C.A.M. van Esch (Onderzoeker); Léon M.J. Knippels (Onderzoeker)

From teh UU repository: "Background: Oral immunotherapy (OIT) is a promising therapeutic approach to treat food allergic patients. However, there are some concerns regarding its safety and long-term efficacy. The use of non-digestible oligosaccharides might improve OIT efficacy since they are known to …

2017GezondheidArtikel

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Dietary Supplementation with Nondigestible Oligosaccharides Reduces Allergic Symptoms and Supports Low Dose Oral Immunotherapy in a Peanut Allergy Mouse Model

The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models

Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model

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