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Effect of organisational factors on the variation in incidence of delirium in intensive care unit patients: A systematic review and meta-regression analysis

Paul Rood; G. Huisman - de Waal; H. Vermeulen; Lisette Schoonhoven; Peter Pickkers; Mark van den Boogaard

2018AlgemeenArtikel

Prophylactic Haloperidol for Critically Ill Adults—Reply

Mark van den Boogaard; A. J. C. Slooter; Peter Pickkers

2018AlgemeenArtikel

Feasibility of Cognitive Training in Critically Ill Patients: A Pilot Study

Mark van den Boogaard; A. Wassenaar; Paul Rood; D. Boelen; Lisette Schoonhoven; Peter Pickkers

2018AlgemeenArtikel

Delirium in critically ill patients : Impact on long-term quality of life and cognitive functioning

Lisette Schoonhoven; Theo van Achterberg; A.W.M. Evers; Hans van der Hoeven; Peter Pickkers; Mark van den Boogaard

Prospective 18-month follow-up study to examine the impact of delirium during intensive care unit stay on long-term health-related quality of life and cognitive function in intensive care unit survivors. …

2012AlgemeenArtikel

Biomarkers associated with delirium in critically ill patients and their relation with long-term subjective cognitive dysfunction : Indications for different pathways governing delirium in inflamed and noninflamed patients

Hans van der Hoeven; M. Kox; Peter Pickkers; K. Quinn; Theo van Achterberg; Lisette Schoonhoven; Mark van den Boogaard

Delirium occurs frequently in critically ill patients and is associated with disease severity and infection. Although several pathways for delirium have been described, biomarkers associated with delirium in intensive care unit (ICU) patients is not well studied. We examined plasma biomarkers in delirious …

2011AlgemeenArtikel

Incidence and short-term consequences of delirium in critically ill patients : A prospective observational cohort study

Lisette Schoonhoven; Hans van der Hoeven; Theo van Achterberg; Peter Pickkers; Mark van den Boogaard

Delirium is a serious and frequent psycho-organic disorder in critically ill patients. Reported incidence rates vary to a large extent and there is a paucity of data concerning delirium incidence rates for the different subgroups of intensive care unit (ICU) patients and their short-term health consequences. …

2011AlgemeenArtikel

Urinary protein profiling in hyperactive delirium and non-delirium cardiac surgery ICU patients

R. van Swelm; Hans van der Hoeven; S. Heemskerk; Peter Pickkers; F. Russel; R. Masereeuw; Mark van den Boogaard

Suitable biomarkers associated with the development of delirium are still not known. Urinary proteomics has successfully been applied to identify novel biomarkers associated with various disease states, but its value has not been investigated in delirium patients. In a prospective explorative study hyperactive …

2011AlgemeenArtikel

Endotoxemia-induced inflammation and the effect on the human brain

Lisette Schoonhoven; Mark van den Boogaard; Hans van der Hoeven; I. Fick; B. Ramakers; N. van Alfen; S. van der Werf; M. Verbeek; A. Hoedemaekers; Peter Pickkers

Effects of systemic inflammation on cerebral function are not clear, as both inflammation-induced encephalopathy as well as stress-hormone mediated alertness have been described. Experimental endotoxemia (2 ng/kg Escherichia coli lipopolysaccharide [LPS]) was induced in 15 subjects, whereas 10 served …

2010AlgemeenArtikel

The impact of delirium in the prediction of In-Hospital Mortality in Intensive Care patients

Martijn Peters; Lisette Schoonhoven; Peter Pickkers; Pieter Leffers; Mark van den Boogaard; Hans van der Hoeven; Pieter Dagnelie

Predictive models, such as acute physiology and chronic health evaluation II (APACHE-II), are widely used in intensive care units (ICUs) to estimate mortality. Although the presence of delirium is associated with a higher mortality in ICU patients, delirium is not part of the APACHE-II model. The aim …

2010AlgemeenArtikel

Assessment of delirium in ICU patients : A literature review

Lisette Schoonhoven; Peter Pickkers; Mark van den Boogaard

A psycho-organic disorder such as delirium is a frequently occurring and serious disorder especially on Intensive Care units. Nowadays, more attention is paid to this problem by physicians, nurses and by researchers, but assessment of delirium in all ICU patients is still not common practice. If patients …

2010AlgemeenArtikel

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