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Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders

Michael G Diemar (Onderzoeker); Mathieu Vinken (Onderzoeker); Marc Teunis (Onderzoeker); Cyrille Krul (Lector); François Busquet (Onderzoeker); Julia Dominika Zajac (Onderzoeker); Helena Kandarova (Onderzoeker); Raffaella Corvi (Onderzoeker); Matteo Z Rosso (Onderzoeker); Anastasiia Kharina (Onderzoeker); Louise Stab Bryndum (Onderzoeker); Michael Santillo (Onderzoeker); Denise Bloch (Onderzoeker); Olena Kucheryavenko (Onderzoeker); Demosthenes Panagiotakos (Onderzoeker); Vera Rogiers (Onderzoeker); Manon Beekhuijzen (Onderzoeker); Arianna Giusti (Onderzoeker); Abdulkarim Najjar (Onderzoeker); Carol Courage (Onderzoeker); Torben Koenig (Onderzoeker); Susanne Kolle (Onderzoeker); Harrie Boonen (Onderzoeker); Stephane Dhalluin (Onderzoeker); Julie Boberg (Onderzoeker); Boris P Müller (Onderzoeker); Predrag Kukic (Onderzoeker); Merel Ritskes-Hoitinga (Onderzoeker); Elena Grasselli (Onderzoeker); Tamara Zietek (Onderzoeker); Gilly Stoddart (Onderzoeker); Harm Heusinkveld (Onderzoeker); Jose V Castell (Onderzoeker); Emilio Benfenati (Onderzoeker); Huan Yang (Onderzoeker); Simón Perera (Onderzoeker); Alicia Paini (Onderzoeker); Nynke Kramer (Onderzoeker); Thomas Hartung (Onderzoeker); Manoe Janssen (Onderzoeker); Ellen Fritsche (Onderzoeker); Danyel Jennen (Onderzoeker); Matteo Piumatti (Onderzoeker); James Rathman (Onderzoeker); Jörg Marusczyk (Onderzoeker); Lucia Milec (Onderzoeker); Erwin Roggen (Onderzoeker)

The first Stakeholder Network Meeting of the EU Horizon 2020-funded ONTOX project was held on 13-14 March 2023, in Brussels, Belgium. The discussion centred around identifying specific challenges, barriers and drivers in relation to the implementation of non-animal new approach methodologies (NAMs) and …

2024GezondheidArtikel

Beyond Animal Testing Index: Benchmarking Tool for a World beyond Animal Testing

Cyrille Krul (Lector); Annick de Moor (Onderzoeker); Koen Stegmeijer (Onderzoeker); Reinout Stoop (Onderzoeker); Judith van Luijk (Onderzoeker); Jan-Bas Prins (Onderzoeker)

While the original definition of replacement focuses on the replacement of the use of animals in science, a more contemporary definition focuses on accelerating the development and use of predictive and robust models, based on the latest science and technologies, to address scientific questions without …

2024GezondheidArtikel

Effects of Exercise during Chemo- or Radiotherapy on Immune Markers

Anne de Hoop (Onderzoeker); Karin Valkenet (Onderzoeker); Jaap Dronkers (Onderzoeker); Cyrille Krul (Lector); Jelle Ruurda (Onderzoeker); Cindy Veenhof (Lector); Raymond Pieters (Lector)

Introduction: Patients with cancer receiving radio- or chemotherapy undergo many immunological stressors. Chronic regular exercise has been shown to positively influence the immune system in several populations, while exercise overload may have negative effects. Exercise is currently recommended for …

2023GezondheidArtikel

DARTpaths, an in silico platform to investigate molecular mechanisms of compounds

Diksha Balla (Onderzoeker); Marvin Steijaert (Onderzoeker); Eefje Poppelaars (Onderzoeker); Marc Teunis (Onderzoeker); Monique van der Vloet (Onderzoeker); Marie Corradi (Onderzoeker); Elisabeth Dévière (Onderzoeker); Luuk Noothout (Onderzoeker); Wilco Tomassen (Onderzoeker); Martijn Rooseboom (Onderzoeker); Richard Currie (Onderzoeker); Cyrille Krul (Lector); Raymond Pieters (Lector); Vera van Noort (Onderzoeker); Marjolein Wildwater (Onderzoeker)

Summary: Xpaths is a collection of algorithms that allow for the prediction of compound-induced molecular mechanisms of action by integrating phenotypic endpoints of different species; and proposes follow-up tests for model organisms to validate these pathway predictions. The Xpaths algorithms are applied …

2023GezondheidArtikel

Natural language processing in toxicology: Delineating adverse outcome pathways and guiding the application of new approach methodologies

Marie Corradi (Onderzoeker); Alyanne M. de Haan (Onderzoeker); Bernard Staumont (Onderzoeker); Aldert H. Piersma (Onderzoeker); Liesbet Geris (Onderzoeker); Raymond H.H. Pieters (Lector); Cyrille A.M. Krul (Lector); Marc A.T. Teunis (Onderzoeker)

Adverse Outcome Pathways (AOPs) are conceptual frameworks that tie an initial perturbation (molecular initiat- ing event) to a phenotypic toxicological manifestation (adverse outcome), through a series of steps (key events). They provide therefore a standardized way to map and organize toxicological …

2022Gezondheid; …Artikel

Towards a reporting guideline for developmental and reproductive toxicology testing in C. elegans and other nematodes

Monique van der Voet (Onderzoeker); Marc Teunis (Associate Lector); Johanna Louter-Van de Haar (Onderzoeker); Nienke Stigter (Onderzoeker); Diksha Balla (Onderzoeker); Martijn Rooseboom (Onderzoeker); Kimberley Wever (Onderzoeker); Cyrille Krul (Lector); Raymond Pieters (Lector); Marjolein Wildwater (Onderzoeker); Vera van Noort (Onderzoeker)

Implementation of reliable methodologies allowing Reduction, Refinement, and Replacement (3Rs) of animal testing is a process that takes several decades and is still not complete. Reliable methods are essential for regulatory hazard assessment of chemicals where differences in test protocol can influence …

2021GezondheidArtikel

A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands.

V. Agamennone (Onderzoeker); C. Krul (Lector); G. Rijkers (Onderzoeker); R. Kort (Onderzoeker)

Niet beschikbaar

2018-08-06GezondheidArtikel

The Isolated Chicken Eye test to replace the Draize test in rabbits

Menk Prinsen (Onderzoeker); Coenraad F.M. Hendriksen (Onderzoeker); Cyrille Krul (Lector); Ruud A. Woutersen (Onderzoeker)

Prinsen MK, Hendriksen CFM, Krul CAM, Woutersen RA. Regul Toxicol Pharmacol. 2017 Apr;85:132-149. doi: 10.1016/j.yrtph.2017.01.009. Epub 2017 Feb 10. PMID:28192172

2017-02-10GezondheidArtikel

Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells

Stefan Vaessen (Lid Lectoraat); M.M.H. van Lipzig (Onderzoeker); Raymond Pieters (Lector); Cyrille Krul (Lector); Heleen Wortelboer (Onderzoeker); E. van de Steeg (Onderzoeker)

From TU Delft repository: "Intestinal transporter proteins and metabolizing enzymes play a crucial role in the oral absorption of a wide variety of drugs. The aim of the current study was to characterize better available intestinal in vitro models by comparing expression levels of these proteins and …

2017GezondheidArtikel

Human lung epithelial cell cultures for analysis of inhaled toxicants

P.S. Hiemstra (Onderzoeker); G. Grootaers (Onderzoeker); A.M. van der Does (Onderzoeker); Cyrille Krul (Lector); Ingeborg M. Kooter

doi: 10.1016/j.tiv.2017.11.005 / PMID:29155131

2017GezondheidArtikel

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