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Salivary concentrations of secretory leukocyte protease inhibitor and matrix metallopeptidase-9 following a single bout of exercise are associated with intensity and hydration status

Karen Knipping (Onderzoeker); Shirley Kartaram (Onderzoeker); Marc Teunis (Onderzoeker); Nicolaas Zuithoff (Onderzoeker); Nicole Buurman (Onderzoeker); Laura M'Rabet (Onderzoeker); Klaske van Norren (Onderzoeker); Renger Witkamp (Onderzoeker); Raymond Pieters (Lector); Johan Garssen (Onderzoeker)

Aim: To investigate the effects of exercise on salivary concentrations of inflammatory markers by analyzing a panel of 25 inflammatory markers in subjects who had participated in bicycle ergometer tests varying in workload and hydration status. Methods: Fifteen healthy young men (20-35 years) had performed …

2023GezondheidArtikel

Kinetics of Physiological Responses as a Measure of Intensity and Hydration Status During Experimental Physical Stress in Human Volunteers

Shirley Kartaram (Lid Lectoraat); Klaske van Norren; Eric Schoen; Marc Teunis (Associate Lector); Marco Mensink; Martie Verschuren; Laura M'Rabet (Onderzoeker); Isolde Besseling-van der Vaart; Karin Mohrmann; Harriët Wittink (Lector); Johan Garssen; Renger Witkamp; Raymond Pieters (Lector)

Introduction: Strenuous physical stress induces a range of physiological responses, the extent depending, among others, on the nature and severity of the exercise, a person’s training level and overall physical resilience. This principle can also be used in an experimental set-up by measuring time-dependent …

2020-09-04GezondheidArtikel

Plasma citrulline concentration, a marker for intestinal functionality, reflects exercise intensity in healthy young men

Shirley Kartaram (Lid Lectoraat); Marco Mensink; Marc Teunis (Lid Lectoraat); Eric Schoen; Lonneke Janssen - Duijghuijsen; Martie Verschuren; Karin Mohrmann; Laura M'Rabet (Lid Lectoraat); Karen Knipping; Harriët Wittink (Lector); Andy van Helvoort; Johan Garssen; Renger Witkamp; Raymond Pieters (Lector); Klaske van Norren

Background & aims Plasma citrulline concentration is considered to be a marker for enterocyte metabolic mass and to reflect its reduction as may occur during intestinal dysfunction. Strenuous exercise can act as a stressor to induce small intestinal injury. Our previous studies suggest that this comprises …

2019GezondheidArtikel

Dietary Supplementation with Nondigestible Oligosaccharides Reduces Allergic Symptoms and Supports Low Dose Oral Immunotherapy in a Peanut Allergy Mouse Model

Laura Wagenaar (Onderzoeker); Marianne Bol-Schoenmakers (Onderzoeker); Giulio Giustarini (Onderzoeker); Marlotte M. Vonk (Onderzoeker); Betty C.A.M. van Esch (Onderzoeker); Léon M.J. Knippels (Onderzoeker); Johan Garssen (Onderzoeker); Joost Smit (Onderzoeker); Raymond Pieters (Lector)

Abstract 1 Scope A major downside of oral immunotherapy (OIT) for food allergy is the risk of severe side effects. Non‐digestible short‐ and long‐chain fructo‐oligosaccharides (scFOS/lcFOS) reduce allergy development in murine models. Therefore, it is hypothesized that scFOS/lcFOS can also support …

2018-08-13GezondheidArtikel

Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model

Marlotte M. Vonk (Onderzoeker); Mara A.P. Diks (Onderzoeker); Laura Wagenaar (Onderzoeker); J.J. Smit (Onderzoeker); Raymond Pieters (Lector); Johan Garssen (Onderzoeker); Betty C.A.M. van Esch (Onderzoeker); Léon M.J. Knippels (Onderzoeker)

From teh UU repository: "Background: Oral immunotherapy (OIT) is a promising therapeutic approach to treat food allergic patients. However, there are some concerns regarding its safety and long-term efficacy. The use of non-digestible oligosaccharides might improve OIT efficacy since they are known to …

2017GezondheidArtikel

Intra- and inter-laboratory validation of an innovative huFcεRIα-RBL-2H3 degranulation assay for in vitro allergenicity assessment of whey hydrolysates

Marjan Gros; Linda Cox; Johan Garssen; Niels de Jong; Diana Kegler; Reiko Teshima; Peter J. Simons; Laura Kruijssen; Manon van Roest; Raymond Pieters (Lector); Léon M.J. Knippels; Marieke Smits (Lid Lectoraat); Marc Teunis (Lid Lectoraat); Karen Knipping; Louis Boon

from the article: "Cow's milk-derived whey hydrolysates are milk substitutes for cow's milk allergic infants. Safety assessment of these hydrolysates is crucial. Currently, huFcεRIα-RBL-2H3 cells, sensitized with serum IgE from cow's milk allergic patients, are used to assess in vitro residual allergenicity. …

2016-02-24Natuur & LandbouwArtikel

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