An efficient four-step biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3-fluorophenyl)ethanol in enantiomerically pure form is described. This compound is a key intermediate required for the preparation of PF-2341066, a potent inhibitor of c-Met/ALK that is currently in clinical development. …

Bij het aanleren van een motorische vaardigheid komt veel kijken. In dit onderzoek zijn verschillende theorien over motorisch leren onder de loep genomen. Voor en nadelen van de cognitieve theorie van o.a. Schmidt in relatie tot de ecologische benadering van Gibson e.a over het menselijk bewegen zijn …

Setting up strategic alliances and trying to attain the intended goals is a highrisk venture. Most research into this topic is confined to already established alliances. This research will focus on perceived performance risks by organizations considering a possible strategic venture. Following other …

Penicillin acylase (PA) from Escherichia coli can catalyze the coupling of an acyl group to penicillin- and cephalosporin-derived beta-lactam nuclei, a conversion that can be used for the industrial synthesis of beta-lactam antibiotics. The modest synthetic properties of the wild-type enzyme make it …

Intermediate reports of my PhD project which reports the results of a Stated Preference Experiment conducted within 18 companies within the chemical industry

This book is about markets for intermediate skills. It is also about the coordination within and between the (vocational) education system and the (sub-baccalaureate) labor market, and the institutions that govern them. Our goal was to improve our understanding of how particular governance regimes influence …

Centre for ABSTRACT Researchers Hamnebukt JI, Emaus J, Sæther K, Kaum-Nathaus S Background Lateral epicondylitis is a common and complex condition, which is often associated with considerable disability and long absence from work. Therefore, the need for effective and qualitatively high treat¬ment …

In dit paper wordt het actor-centered institutionalism model toegepast om onderzoek te kunnen doen naar flexicurity startegieën. Eerst wordt het actor-centered institutionalism model van Renate Maynt, Frits Scharf en anderen samengevat; daarna wordt geschetst hoe dit model kan worden gebuikt om t.a.v. …

This paper is an intermediate result of a PhD research project undertaken by Lenny Visser with Cees Ruijgrok as supervisor. The final objective of this project is to measure thresholds in logistics outsourcing decisions, especially for the chemical sector. If we are able to measure the relative importance …

Touching happens fewer and fewer by the results of the automation and industrialization (Sluijter, 2002). For some reason, touching is not as usual as it has been in former times. Nowadays, touching became a taboo, especially the growing publicity and the influences of the media upon it, makes that touching …