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Optimal Dosing and Timing of High-Dose Corticosteroid Therapy in Hospitalized Patients With COVID-19

Daenen, Katrijn; Huijben, Jilske A; Boyd, Anders; Bos, Lieuwe D J; Stoof, Sara C M; van Willigen, Hugo; Gommers, Diederik A M P J; Moeniralam, Hazra S; den Uil, Corstiaan A; Juffermans, Nicole P; Kant, Merijn; Valkenburg, Abraham J; Pillay, Janesh; van Meenen, David M P; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J; Dalm, Virgil A S H; van Gorp, Eric C M; Schinkel, Janke; Endeman, Henrik

Background: In hospitalized patients with COVID-19, the dosing and timing of corticosteroids vary widely. Low-dose dexamethasone therapy reduces mortality in patients requiring respiratory support, but it remains unclear how to treat patients when this therapy fails. In critically ill patients, high-dose …

2023-01AlgemeenArtikel

Effectiveness of transmural team-based palliative care in prevention of hospitalizations in patients at the end of life

Flierman, Isabelle; Gieteling, Elske; Van Rijn, Marjon (Centre Of Expertise Urban Vitality); Van Grootven, Bastiaan; van Doorne, Iris (Faculteit Gezondheid); Jamaludin, Faridi S.; Willems, Dick L.; Muller, Majon; Buurman, Bianca M

Background: Team-based palliative care interventions have shown positive results for patients at the end of life in both hospital and community settings. However, evidence on the effectiveness of transmural, that is, spanning hospital and home, team-based palliative care collaborations is limited. Aim: …

2023-01AlgemeenAndersoortig materiaal

Nursing leadership in hospital practice

C.J.M. (Margreet) van der van der Cingel (Lector); Richtsje Andela (Onderzoeker); Hans Barf (Onderzoeker)

Nursing Leadership is an important competence to develop in order to provide quality of care and prevent attrition of nurses. This research program looked into the perceptions and experiences of nurses on practising leadership. Next to that supporting the development of nursing leadership was addressed. …

2023GezondheidArtikel

A study protocol for the validation of a prognostic model with an emphasis on modifiable factors to predict chronic pain after a new episode of acute- or subacute nonspecific idiopathic, non-traumatic neck pain presenting in primary care

Martine J. Verwoerd (Onderzoeker); Harriët Wittink (Lector); François Maissan (Onderzoeker); Sander M.J. van Kuijk (Onderzoeker); Rob J.E.M. Smeets (Onderzoeker)

Background The primary objective of this study is to identify which modifiable and non-modifiable factors are independent predictors of the development of chronic pain in patients with acute- or subacute nonspecific idiopathic, non-traumatic neck pain, and secondly, to combine these to develop and internally …

2023GezondheidArtikel

Patients with and without COVID-19 in the Intensive Care Unit: Physical Status Outcome Comparisons 3 Months after Discharge

Bas Cijs (Onderzoeker); Karin Valkenet (Onderzoeker); Germijn Heijnen (Onderzoeker); Anne Visser‑Meily (Onderzoeker); Marike van der Schaaf (Onderzoeker)

Objective: Many patients with COVID-19 infections were admitted to an intensive care unit (ICU). Physical impairments are common after ICU stays and are associated with clinical and patient characteristics. To date, it is unknown if physical functioning and health status are comparable between patients …

2023GezondheidArtikel

The TeleTriageTeam, Offering Continuity of Personalized Care Through Telemedicine: Development and Evaluation

Janneau Claessens (Onderzoeker); Sigrid Mueller-Schotte (Onderzoeker); Jeannette van Weerden (Onderzoeker); Helianthe Kort (Lector); Saskia Imhof (Onderzoeker); Robert Wisse (Onderzoeker)

Background: The COVID-19 pandemic taught us how to rethink care delivery. It catalyzed creative solutions to amplify the potential of personnel and facilities. This paper presents and evaluates a promptly introduced triaging solution that evolved into a tool to tackle the ever-growing waiting lists at …

2023GezondheidArtikel

Professional competences to promote healthy ageing across the lifespan: a scoping review

Elena Carrillo-Alvarez (Onderzoeker); Míriam Rodríguez-Monforte (Onderzoeker); Carles Fernández-Jané (Onderzoeker); Mireia Solà-Madurell (Onderzoeker); Mariusz Kozakiewicz (Onderzoeker); Mariola Głowacka (Onderzoeker); Mariel Leclère (Onderzoeker); Endrit Nimani (Onderzoeker); Adnan Hoxha (Onderzoeker); Armi Hirvonen (Onderzoeker); Sari Järvinen (Onderzoeker); Miriam van der Velde (Onderzoeker); Meike van Scherpenseel (Onderzoeker); António Alves Lopes (Onderzoeker); Hugo Santos (Onderzoeker); Isabel Guimarães (Onderzoeker); Marietta Handgraaf (Onderzoeker); Christian Grüneberg (Onderzoeker)

As societies age, the development of resources and strategies that foster healthy ageing from the beginning of life become increasingly important. Social and healthcare professionals are key agents in this process; therefore, their training needs to be in agreement with societal needs. We performed a …

2023GezondheidArtikel

Characteristics and health outcomes associated with activation for self-management in patients with non-specific low back pain: A cross-sectional study

Tjarco Koppenaal (Onderzoeker); Joost van der Heiden (Onderzoeker); Corelien Kloek (Onderzoeker); Remco M. Arensman (Onderzoeker); Raymond Ostelo (Onderzoeker); Cindy Veenhof (Lector); Martijn Pisters (Onderzoeker)

Background: Research has shown that the course of non-specific low back pain (LBP) is influenced by, among other factors, patients' self-management abilities. Therefore, clinical guidelines recommend stimulation of self-management. Enhancing patients' self-management potentially can improve patients' …

2023GezondheidArtikel

Evidence for effect of l-serine, a novel therapy for GRIN2B-related neurodevelopmental disorder.

B. den Hollander; A.R.J. Veenvliet; Marieke Lindenschot; P. van Essen; G. Peters; A. Santos-Gómez; M. Olivella; X. Altafaj; M.M. Brands; B.A.W. Jacobs; C.D. van Karnebeek

RATIONALE: To date, causal therapy is potentially available for GRIN2B-related neurodevelopmental disorder (NDD) due to loss-of-function (LoF) variants in GRIN2B, resulting in dysfunction of the GluN2B subunit-containing N-methyl-d-aspartate receptor (NMDAR). Recently, in vitro experiments showed that …

2023AlgemeenArtikel

Physiotherapy with integrated virtual reality for patients with complex chronic low back pain: protocol for a pragmatic cluster randomized controlled trial (VARIETY study).

S. Slatman; R. Ostelo; H. van Goor; Bart Staal; J. Knoop

BACKGROUND: Chronic low back pain (CLBP) is the most common chronic pain condition worldwide. Currently, primary care physiotherapy is one of the main treatment options, but effects of this treatment are small. Virtual Reality (VR) could be an adjunct to physiotherapy care, due to its multimodal features. …

2023AlgemeenArtikel

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