Synthetic glucocorticoids are potent anti-inflammatory drugs but show dose-dependent metabolic side effects such as the development of insulin resistance and obesity. The precise mechanisms involved in these glucocorticoid-induced side effects, and especially the participation of adipose tissue in this …

Background: Glucocorticoids are potent anti-inflammatory agents used for the treatment of diseases such as rheumatoid arthritis, asthma, inflammatory bowel disease and psoriasis. Unfortunately, usage is limited because of metabolic side-effects, e.g. insulin resistance, glucose intolerance and diabetes. …

Background Information. Core stability has been described to be important for limb motion. We move in a kinetic chain rather than in single segments during complex movements. Furthermore warm-up programs have shown to enhance coordination as well as performance. The combination of the two of them, in …

The European principle of free movement of people enables European citizens to travel and reside freely in other member states. This applies also to students. Besides this legal establishment of rights, the process of harmonization of higher education in Europe has contributed to the ease with which …

This report is the result of a research to press freedom in the European Union. In recent years, several EU-countries have experienced a dramatic fall in the ratings on press freedom. On the other side, EU-member Finland is the highest rated country in the world when it comes to press freedom. The aim …

We need look no further than the use of email communication, mobile phones and cars to understand that technology has wide-ranging social consequences. What is more, designers are plainly not always aware of the social consequences of technology, despite practicing user-centred design. Email, for instance, …

Probleemstelling Het Rijksinstituut voor Volksgezondheid en Milieu signaleert een toenemend gebruik van fractionele lasers voor cosmetische doeleinden waaronder rimpelreductie. Een onderzoek naar de effectiviteit van de niet- ablatieve fractionele laser voor huidveroudering is van belang omdat binnen …

Probleemstelling Pijn bij oncologische patiënten komt veel voor, specifiek in een gevorderd stadium. Vanwege bijwerkingen van pijndempende medicatie wordt de gewenste mate van pijnreductie, voornamelijk in de palliatieve fase, vaak niet behaald. Doelstelling Inzicht verkrijgen betreft het effect van …

Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal …

In previous research a new type of greenhouse with an integrated concentrated photovoltaic system (CPV) was developed based on a circular covering geometry and an integrated filter for reflecting the near infrared radiation (NIR) of the greenhouse and exploiting this radiation in a solar energy system. …