Background Fatness and fitness both influence cardiometabolic risk. Objective The purpose of this study was to investigate whether childhood fatness and increasing fatness from childhood to adolescence are associated with cardiometabolic risk during adolescence and how fitness affects this association. …

Inleiding: De disbalans tussen energie-inname en energieverbruik is de onderliggende oorzaak van het hedendaagse probleem van overgewicht en obesitas. Geactiveerd bruin vetweefsel kan het energieverbruik verhogen. De recente ontdekking dat volwassenen ook actief bruin vetweefsel bezitten zorgt voor een …

Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal …

Aanleiding: Het metabool syndroom (MetS) is een steeds meer voorkomende aandoening. Zo heeft 10% van de vrouwen en 20% van de mannen met een leeftijd tussen de 30-39 jaar het MetS. De prevalentie stijgt met de leeftijd. Behandeling hiervoor is noodzakelijk om hart en vaatziekten en DM II te voorkomen …

Glucocorticoids (GCs), such as prednisolone (PRED), are widely prescribed anti-inflammatory drugs, but their use may induce glucose intolerance and diabetes. GC-induced beta cell dysfunction contributes to these diabetogenic effects through mechanisms that remain to be elucidated. In this study, we hypothesized …

Het bedrijf Phytonics heeft het natuurlijke gezondheidsproduct, ‘‘Gluco balance’’ ontwikkeld, dat paarden met symptomen van insulineresistentie ondersteunt. Voor dit product wordt geclaimd, dat het de gevoeligheid van de insuline cel receptoren verbetert, en dat hiermee de insuline- en glucoseconcentraties …

BACKGROUND: Glucocorticoids (GCs) control expression of a large number of genes via binding to the GC receptor (GR). Transcription may be regulated either by binding of the GR dimer to DNA regulatory elements or by protein-protein interactions of GR monomers with other transcription factors. Although …

Physical activity (PA) and physical fitness (PF) are inversely associated with the clustering of cardiovascular disease (CVD) risk factors (RF) associated with the metabolic syndrome (MS). However, the role of individual components of PA, that is, intensity, duration and volume, and the inter-relationship …

A number of novel nonionic bolaform amphiphiles with nonidentical aldityl head groups, 1-(1-deoxy-D-galactitol-1-ylamino)-6-(1-deoxy-D-glucitol-1-ylamino)hexane, 1-(1-deoxy-D-mannitol-1-ylamino)-6-(1-deoxy-D-glucitol-1-ylamino)hexane, and 1-(1-deoxy-D-galactitol-1-ylamino)-6-(1-deoxy-D-mannitol-1-ylamino)hexane …

Using stable isotope techniques, this study shows that plasma free fatty acid oxidation is not impaired during exercise in non-obese type II diabetic patients.