Ubiquitin (Ub) is a protein which post-translationally modifies other proteins (its target substrates) and determines their cellular fate. Ub can label substrates for degradation, it can also alter the location of their substrates within a cell or even affect their activity. Chains can be formed via …

De boommarter (Martes martes) is een roofdier die voor komt in bossen in heel Europa. Door zijn afhankelijkheid van boomholtes kan het aantal boommarters in een gebied gebruikt worden als indicatie voor de kwaliteit van het bos. Desondanks neemt het aantal boommarters in verschillende Europese landen …

It is estimated that over 30,000 lesions in the DNA are generated per cell per day. In S-phase, lesions in the DNA can stall replication, which can lead to secondary lesions such as DNA double- strand breaks. The DNA damage tolerance (DDT) network enables replication to be continued in the presence of …

DNA-based identification through the use of metabarcoding has been proposed as the next step in the monitoring of biological communities, such as those assessed under the Water Framework Directive (WFD). Advances have been made in the field of metabarcoding, but challenges remain when using complex samples. …

The heterogeneous nature of environmental DNA (eDNA) and its effects on species detection and community composition estimates has been highlighted in several studies in the past decades. Mostly in the context of spatial distribution over large areas, in fewer occasions looking at spatial distribution …

PCR-free techniques such as meta-mitogenomics (MMG) can recover taxonomic composition of macroinvertebrate communities, but sufer from low efciency, as >90% of sequencing data is mostly uninformative due to the great abundance of nuclear DNA that cannot be identifed with current reference databases. …

Rioolwaterzuiveringen zijn de belangrijkste bron van geneesmiddelen en kunstmatige zoetstoffen in oppervlaktewater. De mate waarin rwzi’s deze organische microverontreinigingen verwijderen, lijkt te variëren van locatie tot locatie en/of in de tijd. Oriënterend onderzoek bij zeven rwzi’s in Groningen …

We used proteomic profiling to taxonomically classify extinct, alongside extant bird species using mass spectrometry on ancient bone-derived collagen chains COL1A1 and COL1A2. Proteins of Holocene and Late Pleistocene-aged bones from dodo (Raphus cucullatus) and great auk (Pinguinus impennis), as well …

The species blonde ray (Raja brachyura) and thornback ray (Raja clavata) have been selected for the 2.1 InnoRays project, to get more insight about the status of these stocks in the Greater North Sea. Unstained and stained age determination methods were tested and LFQ data analysis are conducted for …

Mobile Rapid DNA technology is close to being incorporated into crime scene investigations, with the potential to identify a perpetrator within hours. However, the use of these techniques entails the risk of losing the sample and potential evidence, because the device not only consumes the inserted sample, …