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Dementia in people with severe or profound intellectual (and multiple) disabilities

Dekker, Alain D; Wissing, Maureen B G; Ulgiati, Aurora M; Bijl, Bas; van Gool, Gaby; Groen, Marieke R; Grootendorst, Esther S; van der Wal, Ina A; Hobbelen, Johannes S M (Ageing And Allied Health Care); De Deyn, Peter P; Waninge, Aly (Healthy Ageing, Allied Health Care And Nursing)

BACKGROUND: Differentiating dementia from baseline level of functioning is difficult among people with severe/profound intellectual (and multiple) disabilities. Moreover, studies on observable dementia symptoms are scarce. This study examined (a) the relevance of dementia diagnosis, (b) observable symptoms …

2021-11AlgemeenArtikel

The effect of a multidisciplinary lifestyle program for patients with rheumatoid arthritis, an increased risk for rheumatoid arthritis or with metabolic syndrome-associated osteoarthritis

Walrabenstein, Wendy; van der Leeden, Marike; Weijs, Peter (Lectoraat Voeding En Beweging); van Middendorp, Henriët; Wagenaar, Carlijn; van Dongen, Johanna Maria; Nieuwdorp, Max; de Jonge, Catharina Sophia; van Boheemen, Laurette; van Schaardenburg, Dirkjan

Low-grade inflammation and metabolic syndrome are seen in many chronic diseases, including rheumatoid arthritis (RA) and osteoarthritis (OA). Lifestyle interventions which combine different non-pharmacological therapies have shown synergizing effects in improving outcomes in patients with other chronic …

2021-10-18AlgemeenArtikel

Incidence and Practice of Early Prone Positioning in Invasively Ventilated COVID-19 Patients-Insights from the PRoVENT-COVID Observational Study

Stilma, Willemke (Faculteit Gezondheid); van Meenen, David M. P.; Valk, Christel M. A.; de Bruin, Hendrik; Paulus, Frederique (Centre Of Expertise Urban Vitality); Serpa Neto, Ary; Schultz, Marcus J.

We describe the incidence and practice of prone positioning and determined the association of use of prone positioning with outcomes in invasively ventilated patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) in a national, multicenter observational study, …

2021-10AlgemeenArtikel

Mortality associated with early changes in ARDS severity in COVID-19 patients

PRoVENT-COVID

PURPOSE: We investigated changes in ARDS severity and associations with outcome in COVID-19 ARDS patients. METHODS: We compared outcomes in patients with ARDS classified as 'mild', 'moderate' or 'severe' at calendar day 1, and after reclassification at calendar day 2. The primary endpoint was 28-day …

2021-10AlgemeenArtikel

SARS-CoV-2 infection in pregnancy during the first wave of COVID-19 in the Netherlands: a prospective nationwide population-based cohort study (NethOSS)

E.M. Overtoom; A.N. Rosman; J.J. Zwart; T.E. Vogelvang; T. van den Akker; K.W.M. Bloemenkamp

Objective To describe characteristics, risk factors and maternal, obstetric and neonatal outcomes of pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Design Multi-centre prospective population-based cohort study. Setting Nationwide study in the Netherlands. Population Pregnant …

2021-09-08GezondheidArtikel

Association of intensity of ventilation with 28-day mortality in COVID-19 patients with acute respiratory failure

PRoVENT-COVID

BACKGROUND: The intensity of ventilation, reflected by driving pressure (ΔP) and mechanical power (MP), has an association with outcome in invasively ventilated patients with or without acute respiratory distress syndrome (ARDS). It is uncertain if a similar association exists in coronavirus disease …

2021-08-06AlgemeenArtikel

Development of SARS-COV-2 inhibitors by fragment based drug discovery

Anne van der Sluis (Student)

The coronavirus disease-19 (COVID-19) pandemic still poses serious threats to global public health. Therefore, the scientific community is desperately looking for suitable vaccines and pharmacological treatment options. This thesis completes the internship at Specs Compound Handling BV and describes …

2021-06-16GezondheidBachelor

Physical Activity and Sedentary Behavior in Cardiac Rehabilitation: Does Body Mass Index Matter?

Iris den Uijl (Onderzoeker); Nienke ter Hoeve (Onderzoeker); Madoka Sunamura (Onderzoeker); Mattie J. Lenzen (Onderzoeker); Hanneke Braakhuis (Onderzoeker); Henk J. Stam (Onderzoeker); Eric Boersma (Onderzoeker); Rita van den Berg-Emons (Onderzoeker)

Objective The purpose of this study was to investigate the relationship between body mass index (BMI) class and physical activity and sedentary behavior in patients with acute coronary syndrome (ACS) during cardiac rehabilitation (CR). Methods This study was a secondary analysis of the OPTICARE trial. …

2021-06-04Recreatie, Beweging & Sport; …Artikel

Subacromiaal pijnsyndroom: is excentrische oefentherapie effectiever in pijndemping en toename schouderfunctie vergeleken met shockwave therapie?

Max Pranger (Student); Berber Roorda (Begeleider)

Schouderproblematiek komt veel voor in de samenleving. Jaarlijks heeft gemiddeld 80% van de schouderklachten betrekking tot de subacromiale ruimte. Deze valt onder de parapluterm Subacromiaal Pijnsyndroom (SAPS). Er is nog geen consensus betreft de beste interventie voor het behandelen van SAPS. In de …

2021-06-01GezondheidBachelor

Heritable connective tissue disorders in childhood

Warnink-Kavelaars, Jessica; de Koning, Lisanne E (Lectoraat Fysiotherapie - Transitie Van Zorg Bij Complexe Patiënten); Rombaut, Lies; Alsem, Mattijs W; Menke, Leonie A; Oosterlaan, Jaap; Buizer, Annemieke I; Engelbert, Raoul H H (Centre Of Expertise Urban Vitality); On Behalf Of The Pediatric Heritable Connective Tissue Disorders Study Group

Heritable Connective Tissue Disorders (HCTD) show an overlap in the physical features that can evolve in childhood. It is unclear to what extent children with HCTD experience burden of disease. This study aims to quantify fatigue, pain, disability and general health with standardized validated questionnaires. …

2021-05-28AlgemeenArtikel

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