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Application of Caenorhabditis elegans (nematode) and Danio rerio embryo (zebrafish) as model systems to screen for developmental and reproductive toxicity of Piperazine compounds

Peter I. Racza (Onderzoeker); Marjolein Wildwater (Onderzoeker); Martijn Rooseboom (Onderzoeker); Engelien Kerkhof (Onderzoeker); Raymond Pieters (Lector); Elena Santidrian Yebra-Pimentela (Onderzoeker); Ron P. Dirks (Onderzoeker); Herman P. Spaink (Onderzoeker); Chantal Smulders (Onderzoeker); Graham F. Whale (Onderzoeker)

From the article: "To enable selection of novel chemicals for new processes, there is a recognized need for alternative toxicity screening assays to assess potential risks to man and the environment. For human health hazard assessment these screening assays need to be translational to humans, have …

2017-06-27GezondheidArtikel

Preparation and gas sensing properties of nanocomposite polymers on micro-Interdigitated electrodes for detection of volatile organic compounds at room temperature

Q. Nguyen Minh (Onderzoeker); A. Kuijk (Onderzoeker); Sidharam P. Pujari (Onderzoeker); Franc van der Bent (Lid Lectoraat); Jacob Baggerman (Onderzoeker); H.D. Tong (Onderzoeker); Han Zuilhof (Onderzoeker); C.J.M. van Rijn (Onderzoeker)

not available

2017-05-29TechniekArtikel

Potential of floating production for delta and coastal cities

B. Dal Bo Zanon; B. Roeffen; K.M. Czapiewska; R.E. de Graaf; P.R. Mooij

The disruption of nutrient cycles caused by human activities such as agriculture and burning fossil fuels is impacting ecosystem services on global and local scales. The increasing concentration of carbon dioxide in the atmosphere contributes to rising global temperatures and ocean acidification, whereas …

2017-03-08Techniek; …Artikel

Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells

Stefan Vaessen (Lid Lectoraat); M.M.H. van Lipzig (Onderzoeker); Raymond Pieters (Lector); Cyrille Krul (Lector); Heleen Wortelboer (Onderzoeker); E. van de Steeg (Onderzoeker)

From TU Delft repository: "Intestinal transporter proteins and metabolizing enzymes play a crucial role in the oral absorption of a wide variety of drugs. The aim of the current study was to characterize better available intestinal in vitro models by comparing expression levels of these proteins and …

2017GezondheidArtikel

N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2

YA Wang (Onderzoeker); P. Plastina (Onderzoeker); Jean-Paul Vincken (Onderzoeker); Renate Jansen (Onderzoeker); Michiel Balvers (Onderzoeker); Jean Paul ten Klooster (Lid Lectoraat); Harry Gruppen (Onderzoeker); Renger Witkamp (Onderzoeker); Jocelijn Meijerink (Onderzoeker)

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.6b00298 From teh publisher: "Several studies indicate that the n-3 long-chain polyunsaturated fatty acid docosahexaenoic acid (DHA) contributes to an attenuated inflammatory status in the development of neurodegenerative disorders, such as Alzheimer’s …

2017GezondheidArtikel

Rapid chemoenzymatic route to glutamate transporter inhibitor l -TFB-TBOA and related amino acids

Fu, Haigen; Younes, Sabry H H; Saifuddin, Mohammad; Tepper, Pieter G; Zhang, Jielin; Keller, Erik; Heeres, André (Biobased Ingredients And Materials); Szymanski, Wiktor; Poelarends, Gerrit J

The complex amino acid (l-threo)-3-[3-[4-(trifluoromethyl)benzoylamino]benzyloxy]aspartate (l-TFB-TBOA) and its derivatives are privileged compounds for studying the roles of excitatory amino acid transporters (EAATs) in regulation of glutamatergic neurotransmission, animal behavior, and in the pathogenesis …

2017AlgemeenArtikel

Prediction of carcinogenic potential of chemicals using repeated-dose (13-week) toxicity data

Mirjam Luijten; Jan van Benthem; E.D. Kroese; Ruud A. Woutersen; Cyrille A.M. Krul (Lector); Ans E.M.F. Soffers; Jan Willem van der Laan

From the article: Abstract Sub-chronic toxicity studies of 163 non-genotoxic chemicals were evaluated in order to predict the tumour outcome of 24-month rat carcinogenicity studies obtained from the EFSA and ToxRef databases. Hundred eleven of the 148 chemicals that did not induce putative preneoplastic …

2016-09-08Gezondheid; …Artikel

Monoterpene isolated from the essential oil of Trachyspermum ammi is cytotoxic to multidrug-resistant Pseudomonas aeruginosa and Staphylococcus aureus strains

Fereshteh Jabalameli (Onderzoeker); Farideh Hosseinkhani (Onderzoeker); Maryam Banar (Onderzoeker); Nafiseh Abdellahi (Onderzoeker); Morovat Taherikalani (Onderzoeker); Willem van Leeuwen (Lector); Mohammad Emaneini (Onderzoeker)

INTRODUCTION: The aim of this study was to determine whether an herbal extract containing monoterpene exhibited activity against multidrug-resistant Staphylococcus aureus and Pseudomonas aeruginosa isolated from clinical infection samples. METHODS: The essential oil of Trachyspermum ammi (L.) Sprague …

2016Natuur & LandbouwArtikel

Integrating in vitro data and physiologically based kinetic (PBK) modelling to assess the in vivo potential developmental toxicity of a series of phenols

Strikwold, M. (Lector); Spenkelink, B.; Haan, L.H.J. de

Toxicity outcomes derived in vitro do not always reflect in vivo toxicity values, which was previously observed for a series of phenols tested in the embryonic stem cell test (EST). Translation of in vitro data to the in vivo situation is therefore an important, but still limiting step for the use of …

2016GezondheidArtikel

Diels-Alders adducts of C60 and esters of 3-(1-indenyl)-propionic acid

Sieval, Alex (Biorefinery); Treat, Neil D; Rozema, Desirée; Hummelen, Jan C; Stingelin, Natalie

A series of new, easily synthesized C60-fullerene derivatives is introduced that allow for optimization of the interactions between rr-P3HT and the fullerene by systematic variation of the size of the ester group. Two compounds gave overall cell efficiencies of 4.8%, clearly outperforming [60]PCBM which …

2015-05-11AlgemeenArtikel

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