Background Merkel cell carcinoma (MCC) is a rare, aggressive, neuroendocrine skin tumor with frequent local recurrence, lymph node involvement, distant metastasis, and a high mortality rate. Viscum album extracts (VAE) are a widely used adjunct in cancer treatment and show cytotoxic and immune-modulating …

The thesis at hand was written for the client “Intercruises Shoreside and Port Services”, more specifically their office in Amsterdam, the Netherlands. Intercruises is a tour operator specialized in services for the ocean and river cruise industry. The company already established offices over the whole …

Optimizing physical performance is a major goal in current physiology. However, basic understanding of combining high sprint and endurance performance is currently lacking. This study identifies critical determinants of combined sprint and endurance performance using multiple regression analyses of physiologic …

This chapter presents the currently not established and identifies design requirements for new systems to address this challenge and provide directions for possible improvement. As a result, this chapter introduces the concept of SamenMarkt®, a participatory system in which multi-agent system technology …

During the timespan of the implementation of a system, the why and what against the actual state of the system can change. This difference is referred to as the design problem. Currently, no design problems are identified in Business Rules Management (BRM) and Business Rules Management System (BRMS) …

The adaptation of urbanised areas to climate change is currently one of the key challenges in the domain of urban policy. The diversity of environmental determinants requires the formulation of individual plans dedicated to the most significant local issues. This article serves as a methodic proposition …

Background: Recent theoretical models emphasize the role of impulsive processes in alcohol addiction, which can be retrained with computerized Cognitive Bias Modification (CBM) training. In this study, the focus is on action tendencies that are activated relatively automatically. Objective: The aim of …

CONCORDIA - the greatest level of craftsmanshipThe transformation of a former textile factory into a University of Craft with the ambition for a improvement strategy of a small Polish town, Bolesławiec. INTRODUCTION We are citizens of the world, we travel long distances and seek new advantures. But …

Purpose: The purpose of this systematic review was to assess whether LBP patients demonstrate signs of splinting by evaluating the reactions to unexpected mechanical perturbations in terms of (1) trunk muscle activity, (2) kinetic and (3) kinematic trunk responses and (4) estimated mechanical properties …

The protein transition from animal towards plant proteins, is driven by the growth of the world’s population combined with a rising standard of living. Over the last five years, this has already resulted in a 7-fold increase in product launches with a plant-based claim or notification. This manuscript …