The primary cause of death in breast cancer cases is often metastasis, the spread of cancer cells systemically and the formation of secondary tumors in distant organs of the body. The invasion of breast tumor cells into the surrounding tissue is an initial step in the metastatic cascade. In addition …

Clonal haematopoiesis of intermediate potential (CHIP) driven by somatic mutations in DNMT3A and TET2 has been recently recognized as a new risk factor for cardiovascular diseases (CVD). The haematopoietic clones with mutations in these genes are frequently found in myeloid malignancies and according …

Objectives To investigate cartilage tissue turnover in response to a supervised 12-week exercise-related joint loading training program followed by a 6-month period of unsupervised training in patients with knee osteoarthritis (OA). To study the difference in cartilage tissue turnover between high- and …

Interprofessional collaboration (IPC) is of great importance in the complex care of frail older people. IPC goes beyond multidisciplinary collaboration and ties in with trends and developments in health care that can further improve the quality of health care. However, IPC can be obstructed when it is …

Abstract In this study, we compared cognitive map formation of small-scale models of city-like environments presented in visual or tactile/haptic modalities. Previous research often addresses only a limited amount of cognitive map aspects. We wanted to combine several of these aspects to elucidate a …

The Dutch Republic underwent a process of state formation, accelerated economic growth and military reforms during the Eighty Years War. In particular between 1585 and 1621, Dutch merchant-entrepreneurs built up a burgeoning arms industry and sector of arms exports. These exports required a system of …

Purpose: Exercise therapy with a focus on muscle strengthening has proven to be effective for the management of knee osteoarthritis (OA). Yet it is not known whether high-intensity resistance training (RT) is more effective in improving upper leg muscle strength and physical performance than low-intensity …

Klotho knock-out mice are an important model for vascular calcification, which is associated with chronic kidney disease. In chronic kidney disease, serum magnesium inversely correlates with vascular calcification. Here we determine the effects of serum magnesium on aortic calcification in Klotho knock-out …

The wide use of social media has facilitated new social practices that influence place meaning. This paper uses a double case study of two neighborhood blogs in gentrifying communities, to explore the role of social media in sharing place associations and community formation. Drawing on Collins’ theory …

The Dominican Republic (DR) is home to a wide variety of ecosystems and environmental assets, from flourishing tropical rainforests to arid deserts, and from the highest mountain in the Caribbean to a lake that lies 42 meters below sea level. This has caused tourism development to be of national interest. …