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Plasma citrulline concentration, a marker for intestinal functionality, reflects exercise intensity in healthy young men

Shirley Kartaram (Lid Lectoraat); Marco Mensink; Marc Teunis (Lid Lectoraat); Eric Schoen; Lonneke Janssen - Duijghuijsen; Martie Verschuren; Karin Mohrmann; Laura M'Rabet (Lid Lectoraat); Karen Knipping; Harriët Wittink (Lector); Andy van Helvoort; Johan Garssen; Renger Witkamp; Raymond Pieters (Lector); Klaske van Norren

Background & aims Plasma citrulline concentration is considered to be a marker for enterocyte metabolic mass and to reflect its reduction as may occur during intestinal dysfunction. Strenuous exercise can act as a stressor to induce small intestinal injury. Our previous studies suggest that this comprises …

2019GezondheidArtikel

Vegetable oils as carbon and energy source for Aureobasidium melanogenum in batch cultivation

Nieuwenhuijzen, E. (Elke) van (Researcher); Sailer, M. (Michael) (Researcher); Heuvel, E.R. (Edwin) van den (Researcher); Rensink, S. (Stephanie) (Researcher); Adan, O.C.G. (Olaf) (Researcher); Samson, R. (Robert) (Researcher)

Dark homogenous fungal-based layers called biofinishes and vegetable oils are keyingredients of an innovative wood protecting system. The aim of this study was todetermine which of the vegetable oils that have been used to generate biofinishes onwood will provide carbon and energy for the biofinish-inhabiting …

2018-10-01AlgemeenArtikel

Dietary Supplementation with Nondigestible Oligosaccharides Reduces Allergic Symptoms and Supports Low Dose Oral Immunotherapy in a Peanut Allergy Mouse Model

Laura Wagenaar (Onderzoeker); Marianne Bol-Schoenmakers (Onderzoeker); Giulio Giustarini (Onderzoeker); Marlotte M. Vonk (Onderzoeker); Betty C.A.M. van Esch (Onderzoeker); Léon M.J. Knippels (Onderzoeker); Johan Garssen (Onderzoeker); Joost Smit (Onderzoeker); Raymond Pieters (Lector)

Abstract 1 Scope A major downside of oral immunotherapy (OIT) for food allergy is the risk of severe side effects. Non‐digestible short‐ and long‐chain fructo‐oligosaccharides (scFOS/lcFOS) reduce allergy development in murine models. Therefore, it is hypothesized that scFOS/lcFOS can also support …

2018-08-13GezondheidArtikel

Besluitvorming rondom de Non Alcoholische Fatty Liver Disease (NAFLD) en Non-Alcoholische Steatose Hepatitis (NASH) patiënt met fibrosegraad F0-F1, wel of niet terugverwijzen naar de eerstelijnszorg?

Hulsegge, AJ (Anja) (Student)

Probleemstelling: NAFLD/NASH is een aandoening welk samen gaat met aanwezigheid van diabetes mellitus (DMII),verhoogd alat-waarde, hyperlipidemie en cardiovasculaire aandoeningen. De fibroscan® is een gevalideerd instrument welk de mate van leverfibrose vaststelt. Aantal NASH/NAFLD patiënten in tweedelijnszorg …

2017-09-01GezondheidMaster

Comparison of the ‘ESPEN guidelines on nutrition in cancer patients 2016’ with the recommendations of the Dutch Dietitians in Oncology Group

Kok, Annemieke; Doornink, Niki; Ariens, Marleen; Beijer, Sandra; van den Berg, Manon; Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing); van Lieshout, Rianne; Sijtema, Bea; van Veen, Merel; Breedveld-Peters, Jose

Rationale: In 2016, a completely revised second version of the ‘Handbook Nutrition in Cancer’ (HNC, in Dutch) by the Dutch Dietitians Oncology Group (DDOG) was published. In this project, the DDOG evaluated similarities and potential discrepancies between DDOG recommendations and the ESPEN guidelines …

2017-08AlgemeenConferentiebijdrage

Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model

Marlotte M. Vonk (Onderzoeker); Mara A.P. Diks (Onderzoeker); Laura Wagenaar (Onderzoeker); J.J. Smit (Onderzoeker); Raymond Pieters (Lector); Johan Garssen (Onderzoeker); Betty C.A.M. van Esch (Onderzoeker); Léon M.J. Knippels (Onderzoeker)

From teh UU repository: "Background: Oral immunotherapy (OIT) is a promising therapeutic approach to treat food allergic patients. However, there are some concerns regarding its safety and long-term efficacy. The use of non-digestible oligosaccharides might improve OIT efficacy since they are known to …

2017GezondheidArtikel

N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2

YA Wang (Onderzoeker); P. Plastina (Onderzoeker); Jean-Paul Vincken (Onderzoeker); Renate Jansen (Onderzoeker); Michiel Balvers (Onderzoeker); Jean Paul ten Klooster (Lid Lectoraat); Harry Gruppen (Onderzoeker); Renger Witkamp (Onderzoeker); Jocelijn Meijerink (Onderzoeker)

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.6b00298 From teh publisher: "Several studies indicate that the n-3 long-chain polyunsaturated fatty acid docosahexaenoic acid (DHA) contributes to an attenuated inflammatory status in the development of neurodegenerative disorders, such as Alzheimer’s …

2017GezondheidArtikel

Docosahexaenoyl Serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23–IL-17 signalling in macrophages

Jean Paul ten Klooster (Lid Lectoraat); Raymond Pieters (Lector); Mieke Polanda; Zheng Wang; Renger Witkamp; Jocelijn Meijerink; Mark Boekschoten

Abstract from the article: "Conjugates of fatty acids and amines, including endocannabinoids, are known to play important roles as endogenous signaling molecules. Among these, the ethanolamine conjugate of the n-3 poly unsaturated long chain fatty acid (PUFA) docosahexaenoic acid (22:6n-3) (DHA) was …

2016-09-26Gezondheid; …Artikel

Selection of oleaginous yeasts for fatty acid production

Dennis Lamers; N. van Biezen; D. Martens; L. Peters; E. van de Zilver; N. Jacobs-van Dreumel; R.H. Wijffels; Christien Lokman

Background Oleaginous yeast species are an alternative for the production of lipids or triacylglycerides (TAGs). These yeasts are usually non-pathogenic and able to store TAGs ranging from 20 % to 70 % of their cell mass depending on culture conditions. TAGs originating from oleaginous yeasts can be …

2016AlgemeenArtikel

The effect of endurance exercise on intestinal integrity in well‐trained healthy men

Lonneke Janssen - Duijghuijsen; Marco Mensink; Kaatje Lenaerts; Ewa Fiedorowicz; Dorien van Dartel; Jurriaan Mes; Yvette Luiking; Harry Wichers; Renger Witkamp; Klaske van Norren; Shirley Kartaram (Lid Lectoraat); Anne Geijsen; Astrid van der Harst; Martie Verschuren; Leon Knippels; Raymond Pieters (Lector)

Exercise is one of the external factors associated with impairment of intestinal integrity, possibly leading to increased permeability and altered absorption. Here, we aimed to examine to what extent endurance exercise in the glycogen‐depleted state can affect intestinal permeability toward small molecules …

2016GezondheidArtikel

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