OBJECTIVE: PRECIS - 2 is a tool that could improve design insight for trialists. Our aim was to validate the PRECIS - 2 tool, unlike its predecessor, testing the discriminant validity and inter-rater reliability. STUDY DESIGN AND SETTING: Over 80 international trialists, methodologists, clinicians and …

BACKGROUND: Up to 33% of the general population over 50 years of age are affected by nocturnal leg cramps. Currently there are no generally accepted clinical characteristics, which identify nocturnal leg cramps. This study aims to identify these clinical characteristics and to differentiate between them …

Objective Lowered pressure‐pain thresholds have been demonstrated in adults with Ehlers‐Danlos syndrome hypermobility type (EDS‐HT), but whether these findings are also present in children is unclear. Therefore, the objectives of the study were to determine whether generalized hyperalgesia is present …

As the Dutch electric vehicle (EV) fleet continues to expand, so will the amount of charging sessions increase. This expanding demand for energy will add on to the already existing strain on the grid, primarily during peak hours on workdays in the early morning and evening. This growing energy demand …

This article explores ways to assess interactional performance, and reports on the use of a test format that standardizes the interlocutor’s linguistic and interactional contributions to the exchange. It describes the construction and administration of six scripted speech tasks (instruction-, advice-, …

INTRODUCTION: Lowered pressure pain thresholds have been demonstrated in adults with Ehlers-Danlos Hypermobility type(EDS-HT), however it remains unclear if these findings are also present in children. Therefore, the objectives of the study were to: (1)determine if generalized hyperalgesia is present …

The collapse of Enron in 2001 made policy makers developed some new addition to corporate governance regulations. According to OECD (2015) there are 5 principles of good corporate governance which are transparency, fairness, accountability, responsibility and independency. CEOs need to be accountable …

This research was created as a contribution to the internationalization strategy of RAI Amsterdam. The company wants to bring more international conferences, and exhibitions to Amsterdam. One of the objectives of this strategy is to create an ‘international standard’, which complies with the basic services, …

The overlap in symptoms between joint bleeds and flare‐ups of haemophilia arthropathy (HA) creates difficulties in differentiating between the two conditions. Diagnosis of haemarthrosis is currently empirically made based upon clinical presentations. However, no standard diagnostic criteria are available. …