Background: Lung fibroblasts are implicated in abnormal tissue repair in chronic obstructive pulmonary disease (COPD). The exact mechanisms are unknown and comprehensive analysis comparing COPD- and control fibroblasts is lacking. Aim: To gain insight in the role of lung fibroblasts in COPD pathology …

BACKGROUND: Covid-19 has had a major negative impact on children's engagement in health-related behaviors. This study examines trends in children's screen time, outdoor play and sports club membership in pre- (2016-19), mid- (2020-21) and post- (2021-22) Covid years. Also, predicting factors (gender, …

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitochondrial dysfunction is thought to be a key driver of …

The aim of this review was to explore which factors influence nurses' adoption of information and communication technology. A systematic review was conducted using qualitative and quantitative studies. The authors performed the search strategy in the databases of PubMed, CINAHL, and IEEE and included …

The aim of this meta-analysis was to analyze the experimental research into the effects of job-embedded professional development (JEPD) for teachers and student outcomes. Our meta-analysis of experimental studies of the effects JEPD, included 20 studies (with 79 experimental comparisons) at teacher level …

Aim: To investigate associations between participation-related constructs and participation frequency and involvement in inclusive schools. Method: In this cross-sectional study, teachers of children with additional support needs, including intellectual disability, autism, and learning difficulties, …

Objective To evaluate the effectiveness of psychosomatic therapy versus care as usual in primary care for patients with persistent somatic symptoms (PSS). Methods We conducted a pragmatic, two-armed, randomised controlled trial among primary care patients with PSS in the Netherlands that included 39 …

Democratie en burgerschap staan onder druk. We leven in een tijd van affectieve polarisatie waar mensen elkaar niet vanzelf als gerespecteerde gesprekspartners zien, er breed nepnieuws gedeeld wordt, democratische rechten niet per se als vanzelfsprekend worden gezien, de overheid burgers ‘vermorzelt’ …

Technological innovations enable rapid DNA analysis implementation possibilities. Concordantly, rapid DNA devices are being used in practice. However, the effects of implementing rapid DNA technologies in the crime scene investigation procedure have only been evaluated to a limited extent. In this study …

Background Hospital admissions are common in the last phase of life. However, palliative care and advance care planning (ACP) are provided late or not at all during hospital admission. Aim To provide insight into the perceptions of in-hospital healthcare professionals concerning current and ideal practice …