OBJECTIVE: Seventy percent of patients with colorectal cancer (CRC) are aged 65 years or older. Netherlands Comprehensive Cancer Organization (n.d.) [1] Surgery is an important treatment modality, depending on cancer stage and the resectability of the tumor. Frail older patients are at an increased risk …

Purpose: Exercise therapy with a focus on muscle strengthening has proven to be effective for the management of knee osteoarthritis (OA). Yet it is not known whether high-intensity resistance training (RT) is more effective in improving upper leg muscle strength and physical performance than low-intensity …

Purpose: Instability of the knee joint is reported by a majority (>65%) of patients with knee osteoarthritis (KOA) and is hypothesized to play a crucial role in the initiation and progression of KOA. A generally accepted objective metric of knee joint stability is lacking, making development of diagnostics …

Studies of brain size of children classified with ADHD appear to reveal smaller brains when compared to ‘normal’ children. Yet, what does this mean? Even with the use of rigorously screened case and control groups, these studies show only small, average group differences between children with and without …

The aviation industry is a changing industry in which several factors influence the performance of the airport and the network of airports that are interconnected. Business models, technical operations in airspace and in the airfield, societal conditions among others are some of the ones that must be …

In 1990, livestock grazing was introduced in Meijendel, a 1800 ha lime-rich coastal dune area, at a density of 0.06–0.07 LLU.ha-1.year−1 (1:12–18 ha) to counteract encroachment of tall grasses and shrubland on dune grassland and increase the bare sand area. Monitoring was based on four digital orthophotos …

Poland still has a lot of changes ahead that are necessary, especially in rural areas, if Poland wants to reach the climate goals set by the European Union. Bioenergy could be a great option for Poland as it would tackle Poland’s problems with greenhouse gas emissions, air pollution and power interruptions. …

BACKGROUND: In critical care patients, reaching optimal β-lactam concentrations poses challenges, as infections are caused more often by microorganisms associated with higher MICs, and critically ill patients typically have an unpredictable pharmacokinetic/pharmacodynamic profile. Conventional intermittent …

Increased spatial pressures on the marine environment asks for smart use of space in order to safeguard the achievement of environmental, social and economic objectives. Multi-use is seen as a new paradigm for space efficiency and might yield other benefits beyond that. Within the scope of their Policy …

PURPOSE: Fatigue is a common and potentially disabling symptom in patients with cancer. It can often be effectively reduced by exercise. Yet, effects of exercise interventions might differ across subgroups. We conducted a meta-analysis using individual patient data of randomized controlled trials (RCTs) …