Het NKI is een oncologisch onderzoekscentrum waar wetenschappelijk onderzoek gedaan wordt naar verschillende soorten kanker. Op de afdeling Bio-Farmacologie wordt er voornamelijk onderzoek gedaan naar geneesmiddelen, of een combinatie ervan, die hersentumoren bestrijden. Er worden in vitro en in vivo …

Raman spectroscopy is an optical technique that is based on the inelastic scattering of light. It is non-invasive, fast, objective and easy to use. These traits make it an ideal tool for use in medical diagnosis. Melanoma is the deadliest form of skin cancer. Currently, melanomas are visually diagnosed …

Toxicity outcomes derived in vitro do not always reflect in vivo toxicity values, which was previously observed for a series of phenols tested in the embryonic stem cell test (EST). Translation of in vitro data to the in vivo situation is therefore an important, but still limiting step for the use of …

Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal …

The “as eaten” method to measure the Total Dietary Fibre content and an in vitro fermentation with colon bacteria were successfully coupled to see if fibre fractions have a prebiotic effect. Similar growth pattern for modified starch, FOS and GOS were observed (Fig A). The qPCR results indicate a significant …

Microencapsulation of cells is a promising approach to prevent rejection in the absence of immunosuppression. Clinical application, however, is hampered by insufficient insight in factors influencing biocompatibility of the capsules in humans. In the present study we exposed alginate-based capsules prepared …

BACKGROUND: Prednisolone and other glucocorticoids (GCs) are potent anti-inflammatory and immunosuppressive drugs. However, prolonged use at a medium or high dose is hampered by side effects of which the metabolic side effects are most evident. Relatively little is known about their effect on gene-expression …

This report examines Dutch military personnel’s attitudes toward international cooperation, while these attitudes were expressed under threatening (during the International Security Assistance Force (ISAF) mission in Afghanistan) or nonthreatening circumstances (in Europe). Findings indicate that concerns …

The government of Zambia has joined several international co-operatives in order to reduce poverty and improve public healthcare services. Activities concerning nuclear sciences and technology have gained greater importance in Africa during the past decade. Zambia has focused on upgrading the nuclear …

Genomics has multiplied the number of targets for new therapeutic interventions, but this has not yet lead to a marked increase of pharma pipeline outputs. The complexity of protein function in higher order biological systems is often underestimated. Translation from in vitro and in vivo results to the …