Since Factor H is the main regulator of the complement system, any dysregulation may result in either uncontrolled complement activation or inhibition. Auto-antibodies against Factor H inhibit the protective function of Factor H on host cells, which are now sensitive for complement activation. It is …

This study investigates the knowledge that experienced teachers draw on when fostering students’ reflections. Reflective skills are crucial for advancing students’ learning. In order to promote students’ reflection productively, extensive support and scaffolding from teachers is indispensible. However, …

Motivation: Unambiguous sequence variant descriptions are important in reporting the outcome of clinical diagnostic DNA tests. The standard nomenclature of the Human Genome Variation Society (HGVS) describes the observed variant sequence relative to a given reference sequence. We propose an efficient …

We have developed CiVi, a user-friendly web-based tool to create custom circular maps to aid the analysis of microbial genomes and sequence elements. Sequence related data such as gene-name, COG class, PFAM domain, GC%, and subcellular location can be comprehensively viewed. Quantitative gene-related …

Background: Matching and comparing sequence annotations of different reference sequences is vital to genomics research, yet many annotation formats do not specify the reference sequence types or versions used. This makes the integration of annotations from different sources difficult and error prone. Results: …

Small RNAs are important regulators of genome function, yet their prediction in genomes is still a major computational challenge. Statistical analyses of pre-miRNA sequences indicated that their 2D structure tends to have a minimal free energy (MFE) significantly lower than MFE values of equivalently …

Background: G-protein coupled receptors (GPCRs) are involved in many different physiological processes and their function can be modulated by small molecules which bind in the transmembrane (TM) domain. Because of their structural and sequence conservation, the TM domains are often used in bioinformatics …

Het oor is opgebouwd uit het buitenoor, het middenoor en het binnenoor. Het buitenoor wordt onderverdeeld in de oorschelp en de uitwendige (externe) gehoorgang. Wanneer de bescherming van het cerumen en de bescherming van de intacte huid wegvallen in de externe gehoorgang, door bijvoorbeeld een beschadiging …

In this paper the principle of minimum relative entropy (PMRE) is proposed as a fundamental principle and idea that can be used in the field of AGI. It is shown to have a very strong mathematical foundation, that it is even more fundamental then Bayes rule or MaxEnt alone and that it can be related …

Phylogenetic patterns show the presence or absence of certain genes in a set of full genomes derived from different species. They can also be used to determine sets of genes that occur only in certain evolutionary branches. Previously, we presented a database named PhyloPat which allows the complete …