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HELP! Problems in executing a pragmatic, randomized, stepped wedge trial on the Hospital Elder Life Program to prevent delirium in older patients

Noor Heim; Henk F. van Stel; Roelof Ettema (Lid Lectoraat); Roos C. van der Mast; Sharon K. Inouye; Marieke Schuurmans (Lector)

Background: A pragmatic, stepped wedge trial design can be an appealing design to evaluate complex interventions in real-life settings. However, there are certain pitfalls that need to be considered. This paper reports on the experiences and lessons learned from the conduct of a cluster randomized, …

2017GezondheidArtikel

Stop or Go? Preventive cognitive therapy with guided tapering of antidepressants during pregnancy: study protocol of a pragmatic multicentre non-inferiority randomized controlled trial

H. Burger; N.M. Molenaar; H.W. Torij (Lector); G.J. Bonsel; M.P. Lambregtse - van den Berg; W.J.G. Hoogendijk; M.E. Brouwer; C.L.H. Bockting; J.J. Duvekot; C.N. van der Veere

Approximately 6.2% of women in the USA and 3.7% of women in the UK, use Selective Serotonin Reuptake Inhibitors (SSRIs) during their pregnancies because of depression and/or anxiety. In the Netherlands, this prevalence is around 2%. Nonetheless, SSRI use during pregnancy is still controversial. On the …

2016-01-01GezondheidArtikel

The CareWell-primary care program: design of a cluster controlled trial and process evaluation of a complex intervention targeting community-dwelling frail elderly

F.G.H. Ruikes; ARM Meys; G. van de Wetering; R.P. Akkermans; Betsie van Gaal; S.U. Zuidema; H.J. Schers; Theo van Achterberg; R.T.C.M. Koopmans

Background: With increasing age and longevity, the rising number of frail elders with complex and numerous health-related needs demands a coordinated health care delivery system integrating cure, care and welfare. Studies on the effectiveness of such comprehensive chronic care models targeting frail …

2012AlgemeenArtikel

Pragmatic vs. explanatory: an adaptation of the PRECIS tool helps to judge the applicability of systematic reviews for daily practice.

M. Spigt; J.A. Knottnerus; Joris Linmans; Tjarco Koppenaal (Docent)

OBJECTIVE: The Pragmatic-Explanatory Continuum Indicator Summary (PRECIS) tool was designed to classify randomized clinical trials (RCT) as being more pragmatic or explanatory. We modified the PRECIS tool (called PRECIS-Review tool [PR-tool]) to grade individual trials and systematic reviews of trials. …

2010-11-12AlgemeenArtikel

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HELP! Problems in executing a pragmatic, randomized, stepped wedge trial on the Hospital Elder Life Program to prevent delirium in older patients

Stop or Go? Preventive cognitive therapy with guided tapering of antidepressants during pregnancy: study protocol of a pragmatic multicentre non-inferiority randomized controlled trial

The CareWell-primary care program: design of a cluster controlled trial and process evaluation of a complex intervention targeting community-dwelling frail elderly

Pragmatic vs. explanatory: an adaptation of the PRECIS tool helps to judge the applicability of systematic reviews for daily practice.

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