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Chronic pain in hypermobility syndrome and Ehlers-Danlos syndrome (hypermobility type)

Scheper, Mark C; de Vries, Janneke E; Verbunt, Jeanine; Engelbert, Raoul HH

Generalized joint hypermobility (GJH) is highly prevalent among patients diagnosed with chronic pain. When GJH is accompanied by pain in ≥4 joints over a period ≥3 months in the absence of other conditions that cause chronic pain, the hypermobility syndrome (HMS) may be diagnosed. In addition, GJH is …

2015AlgemeenArtikel

Diversity in robustness of Lactococcus lactis strains during heat stress, oxidative stress, and spray drying stress

Dijkstra, Annereinou R; Setyawati, Meily C; Bayjanov, Jumamurat R; Alkema, Wynand (Data Science For Life Science & Health); van Hijum, Sacha A F T; Bron, Peter A; Hugenholtz, Jeroen

In this study we tested 39 Lactococcus lactis strains isolated from diverse habitats for their robustness under heat and oxidative stress, demonstrating high diversity in survival (up to 4 log units). Strains with an L. lactis subsp. lactis phenotype generally displayed more-robust phenotypes than strains …

2014-01-15AlgemeenArtikel

The role of Coproporphyrinogen III oxidase and Ferrochelatase genes in heme biosynthesis and regulation in Aspergillus niger

C.A. van den Hondel; P.J. Punt; H. Haas; Arthur F.J. Ram; M. Werner; S. de Weert; A.C. Franken; Christien Lokman

Heme is a suggested limiting factor in peroxidase production by Aspergillus spp., which are well-known suitable hosts for heterologous protein production. In this study, the role of genes coding for coproporphyrinogen III oxidase (hemF) and ferrochelatase (hemH) was analyzed by means of deletion and …

2013AlgemeenArtikel

Is joint hypermobility associated with vesico-ureteral reflux? An assessment of 50 patients

van Eerde, Albertien M.; Verhoeven, Virginie J.M.; de Jong, Tom P.V.M.; van de Putte, Elise M.; Giltay, Jacques C.; Engelbert, Raoul H.H.

Study Type – Aetiology (individual cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Recent studies have already shown associations between generalized joint hypermobility (GJH) and voiding and defecation dysfunction and/or slow transit constipation. Changes in extracellular …

2012-04AlgemeenArtikel

Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

Smeets, Ruben L; Fleuren, Wilco W M; He, Xuehui; Vink, Paul M; Wijnands, Frank; Gorecka, Monika; Klop, Henri; Bauerschmidt, Sussane; Garritsen, Anja; Koenen, Hans J P M; Joosten, Irma; Boots, Annemieke M H; Alkema, Wynand (Data Science For Life Science & Health)

BACKGROUND: T lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into Th1, Th2, Th17 or iTreg phenotypes, depending on environmental co-stimulatory signals. To identify genes and pathways involved in differentiation of Jurkat T cells towards Th1 and Th2 subtypes we performed …

2012-03-14AlgemeenArtikel

Dysphagia is present but mild in myotonic dystrophy type 2

R. Ensink; Bert de Swart; J. van Vliet; A. Tieleman; Marscha Engelen; S. Knuijt

The phenotype of myotonic dystrophy type 2 (DM2) shows similarities as well as differences to that of myotonic dystrophy type 1 (DM1). Dysphagia, a predominant feature in DM1, has not yet been examined in DM2. In a recent nationwide questionnaire survey of gastrointestinal symptoms in DM2, 12 out of …

2009AlgemeenArtikel

Alternative primer sets for PCR detection of genotypes involved in bacterial aerobic BTEX degradation

Hendrickx, Barbara; Junca, Howard; Vosahlova, Jolana; Lindner, Antje; Rüegg, Irene; Bucheli-Witschel, Margarete; Faber, Folkert (Life Sciences & Renewable Energy); Egli, Thomas; Mau, Margit; Schlömann, Michael; Brennerova, Maria; Brenner, Vladimir; Pieper, Dietmar H; Top, Eva M; Dejonghe, Winnie; Bastiaens, Leen; Springael, Dirk

Eight new primer sets were designed for PCR detection of (i) mono-oxygenase and dioxygenase gene sequences involved in initial attack of bacterial aerobic BTEX degradation and of (ii) catechol 2,3-dioxygenase gene sequences responsible for meta-cleavage of the aromatic ring. The new primer sets allowed …

2006-02-01AlgemeenArtikel

Transcriptional profiling reveals complex regulation of the monocyte IL-1 beta system by IL-13

Scotton, Chris J; Martinez, Fernando O; Smelt, Maaike J; Sironi, Marina; Locati, Massimo; Mantovani, Alberto; Sozzani, Silvano

IL-4 and IL-13 are prototypic Th2 cytokines that generate an “alternatively activated” phenotype in macrophages. We used high-density oligonucleotide microarrays to investigate the transcriptional profile induced in human monocytes by IL-13. After 8-h stimulation with IL-13, 142 genes were regulated …

2005-01-15AlgemeenArtikel

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