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GMP Compliant Synthesis of Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2

Heeres, André (Biobased Chemistry & Refinery); van der Hoek, Sjoukje; Antunes, Inês F.; Attia, Khaled A.; Jacquet, Olivier; Bulthuis, Marian; Zijlma, Rolf; Boersma, Hendrikus H.; van Goor, Harry; Visser, Ton J.; Heerspink, Hiddo J. L.; Elsinga, Philip H.; Stevens, Jasper

Inhibition of the sodium−glucose cotransporter 2 (SGLT2) by canagliflozin in type 2 diabetes mellitus results in large between-patient variability in clinical response. To better understand this variability, the positron emission tomography (PET) tracer [18F]canagliflozin was developed via a Cu-mediated …

2021-11-08AlgemeenArtikel

GMP Compliant Synthesis of [18F]Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2

van der Hoek, Sjoukje; Antunes, Inês F.; Attia, Khaled A.; Jacquet, Olivier; Heeres, André (Biobased Chemistry & Refinery); Bulthuis, Marian; Zijlma, Rolf; Boersma, Hendrikus H.; van Goor, Harry; Visser, Ton J.; Heerspink, Hiddo J. L.; Elsinga, Philip H.; Stevens, Jasper

Inhibition of the sodium–glucose cotransporter 2 (SGLT2) by canagliflozin in type 2 diabetes mellitus results in large between-patient variability in clinical response. To better understand this variability, the positron emission tomography (PET) tracer [18F]canagliflozin was developed via a Cu-mediated …

2021-11-08AlgemeenArtikel

Application of ultrasound for muscle assessment in sarcopenia

Perkisas, Stany; Bastijns, Sophie; Baudry, Stéphane; Bauer, Jürgen; Beaudart, Charlotte; Beckwée, David; Cruz-Jentoft, Alfonso; Gasowski, Jerzy; Hobbelen, Hans (Ageing And Allied Health Care); Jager-Wittenaar, Harriët; Kasiukiewicz, Agnieszka; Landi, Francesco; Małek, Magdalena; Marco, Ester; Martone, Anna Maria; de Miguel, Ana Merello; Piotrowicz, Karolina; Sanchez, Elisabet; Sanchez-Rodriguez, Dolores; Scafoglieri, Aldo; Vandewoude, Maurits; Verhoeven, Veronique; Wojszel, Zyta Beata; De Cock, Anne-Marie

PURPOSE: In 2018, the SARCUS working group published a first article on the standardization of the use of ultrasound to assess muscle. Recommendations were made for patient positioning, system settings and components to be measured. Also, shortcomings in knowledge were mentioned. An important issue that …

2021-02-01AlgemeenArtikel

Wetenschap en Technologie is geen vak apart!

Ester Sloot (Student); Crista Casu (Docent); Anne Schepers (Docent)

Een praktijkonderzoek naar hoe Wetenschap & Technologie geïntegreerd kan worden in het primair onderwijs.

2020-06-25Opvoeding & OnderwijsBachelor

Visit of Minister Cora Nieuwenhuizen to Groningen

Boogaard, Floris

Closer Look: Poster exhibition on climate adaptation studies1. Institutional design for the transition to flood resilience in developing countries, Naim Laeni, Doctoral student, Faculty of Spatial Sciences, University of Groningen2. Living with floods: The rise of civil society in local flood resilience …

2019-09-16Natuur & LandbouwConferentiebijdrage

Communiceren met ouders in het Integraal Kindcentrum

Ester de Bruijn (Student); Trees Das (Begeleider)

Dit onderzoek gaat over de communicatieverschillen tussen opvang en onderwijs in een integraal kindcentrum. Aanleiding was het feit dat er meer ontevredenheid was bij ouders die kinderen in het onderwijs hebben, dan van ouders met kinderen in de opvang. Hoe kan het dat ouders verschillen ervaren en is …

2019-05Opvoeding & OnderwijsMaster

The SARCUS project: evidence-based muscle assessment through ultrasound

Perkisas, Stany; Baudry, Stephane; Bauer, Juergen; Beckwee, David; Decock, Anne; Hobbelen, Johannes (Ageing And Allied Health Care); Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing); Kasiukiewicz, Agnieszka; Landi, Francesco; Marco, Ester; Merello, Ana; Piotrowicz, Karolina; Sanchez, Elisabet; Sanchez-Rodriguez, Dolores; Scafoglieri, Aldo; Cruz-Jentoft, Alfonso; Vandewoude, Maurits

2019-02-15AlgemeenArtikel

Application of ultrasound for muscle assessment in sarcopenia: towards standardized measurements

Perkisas, Stany; Bakker, Stephan; Bauer, Juergen; Beckwee, David; De Cock, Anne-Marie; Hobbelen, Johannes (Ageing And Allied Health Care); Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing); Kasiukiewicz, Agnieszka; Landi, Francesco; Marco, Ester; Merello, Ana; Piotrowicz, Karolina; Sanchez, Elisabet; Sanchez-Rodriguez, Dolores; Scafoglieri, Aldo; Cruz-Jentoft, Alfonso; Vandewoude, Maurits

Purpose: Measurement of muscle mass is paramount in the screening and diagnosis of sarcopenia. Besides muscle quantity however, also quality assessment is important. Ultrasonography (US) has the advantage over dual-energy X-ray absorptiometry (DEXA) and bio-impedance analysis (BIA) to give both quantitative …

2018-12-01AlgemeenArtikel

Filosoferen op CBS De Parel: Filosoferen kan je leren, ook op een christelijke basisschool

Ester Rekers (Student); Job Morsink (Begeleider)

Op CBS De Parel in Hierden wordt met regelmaat getheologiseerd. Zo ontstaan vaak interessante gesprekken, maar altijd in een theologische context. Om dit breder te kunnen trekken, is er in eerder onderzoek gekeken naar de mogelijkheid van het filosoferen. Hieruit bleek dat de interesse hiervoor aanwezig …

2018-06-11Opvoeding & Onderwijs; …Bachelor

A generational approach to female entrepreneurship in Europe

P. Ester; A.A. Román

Female entrepreneurship is still a limited phenomenon in European countries and its promotion ranks high on the EU policy agenda. Various frameworks have been offered to explain the main structural differences in entrepreneurship between men and women, emphasizing a variety of underlying factors. With …

2017-12-26Economie & ManagementArtikel

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