Adverse Outcome Pathways (AOPs) are conceptual frameworks that tie an initial perturbation (molecular initiat- ing event) to a phenotypic toxicological manifestation (adverse outcome), through a series of steps (key events). They provide therefore a standardized way to map and organize toxicological …

In practice, faults in building installations are seldom noticed because automated systems to diagnose such faults are not common use, despite many proposed methods: they are cumbersome to apply and not matching the way of thinking of HVAC engineers. Additionally, fault diagnosis and energy performance …

In March 2020 schools in The Netherlands closed to contain the spread of Covid-19 virus. Shortly after, schools took to online education. The condensed setting of the Covid-19 situation provided a background to study which learning activities and tools teachers choose in online education and how they …

Many countries experience waning public trust in government, while digitisation of society is on the rise and public authorities continue to further digitise their services. If governments do not pay enough attention to the perspective of citizens and adopt a citizen-centric approach while designing …

Medium-sized cities across Europe are increasingly and actively attracting skilled migrants. How can these cities best manage the challenges of internationalisation? That is to say: How can they attract, facilitate and integrate skilled migrants, enabling them to contribute to the regional culture and …

Societal actors across scales and geographies increasingly demand visual applications of systems thinking – the process of understanding and changing the reality of a system by considering its whole set of interdependencies – to address complex problems affecting food and agriculture. Yet, despite the …

Mechanisms that drive the intergenerational transmission of poverty have been studied widely, but to understand how these mechanisms are at work in real life we require studies on perspectives of families who themselves are living in poverty. In this study, we combine the perspectives of multiple generations …

This research examines how Dutch border retailers are responding to business opportunities from cross-border shoppers as a specific target group. Further on, it describes shopping behaviour of German cross-border shoppers in the Netherlands. Interviews about their marketing policy are conducted with …

We present a novel architecture for an AI system that allows a priori knowledge to combine with deep learning. In traditional neural networks, all available data is pooled at the input layer. Our alternative neural network is constructed so that partial representations (invariants) are learned in the …

Low-grade inflammation and metabolic syndrome are seen in many chronic diseases, including rheumatoid arthritis (RA) and osteoarthritis (OA). Lifestyle interventions which combine different non-pharmacological therapies have shown synergizing effects in improving outcomes in patients with other chronic …