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Sputum Proteome Signatures of Mechanically Ventilated Intensive Care Unit Patients Distinguish Samples with or without Anti-pneumococcal Activity

Seinen, Jolien; Engelke, Rudolf; Abdullah, Mohammed R; Voß, Franziska; Michalik, Stephan; Dhople, Vishnu M; Dieperink, Willem; de Smet, Anne Marie G A; Völker, Uwe; van Dijl, Jan Maarten; Schmidt, Frank; Hammerschmidt, Sven

Respiratory pathogens like Streptococcus pneumoniae can cause severe pneumonia. Nonetheless, mechanically ventilated intensive care patients, who have a high risk of contracting pneumonia, rarely develop pneumococcal pneumonia. Mechanically ventilated patients are at risk of contracting pneumonia. Therefore, …

2021-04-27AlgemeenArtikel

Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure

HOT-ICU Investigators

Abstract Background Patients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are treated with supplemental oxygen, but the benefits and harms of different oxygenation targ...

2021-04-08AlgemeenArtikel

Associations of body mass index with ventilation management and clinical outcomes in invasively ventilated patients with ARDS Related to COVID-19

PRoVENT-COVID

We describe the practice of ventilation and mortality rates in invasively ventilated normal-weight (18.5 ≤ BMI ≤ 24.9 kg/m2), overweight (25.0 ≤ BMI ≤ 29.9 kg/m2), and obese (BMI > 30 kg/m2) COVID-19 ARDS patients in a national, multicenter observational study, performed at 22 intensive care units in …

2021-03-11AlgemeenArtikel

Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID)

PRoVENT-COVID

BACKGROUND: Little is known about the practice of ventilation management in patients with COVID-19. We aimed to describe the practice of ventilation management and to establish outcomes in invasively ventilated patients with COVID-19 in a single country during the first month of the outbreak. METHODS: …

2021-02-01AlgemeenArtikel

Development and usability of educational material about workplace particulate matter exposure

J. Bolte (Lector)

Background: Particulate matter (PM) exposure is an important health risk, both in daily life and in the workplace. It causes respiratory and cardiovascular diseases and results in 800,000 premature deaths per year worldwide. In earlier research, we assessed workers’ information needs regarding workplace …

2021TechniekArtikel

Awake Proning as an Adjunctive Therapy for Refractory Hypoxemia in Non-Intubated Patients with COVID-19 Acute Respiratory Failure: Guidance from an International Group of Healthcare Workers

Stilma, Willemke (Faculteit Gezondheid); Åkerman, Eva; Artigas, Antonio; Bentley, Andrew; Bos, Lieuwe D.; Bosman, Thomas J. C.; de Bruin, Hendrik; Brummaier, Tobias; Buiteman-Kruizinga, Laura A.; Carcò, Francesco; Chesney, Gregg; Chu, Cindy; Dark, Paul; Dondorp, Arjen M.; Gijsbers, Harm J. H.; Gilder, Mary Ellen; Grieco, Domenico L.; Inglis, Rebecca; Laffey, John G.; Landoni, Giovanni; Lu, Weihua; Maduro, Lisa M. N.; McGready, Rose; McNicholas, Bairbre; de Mendoza, Diego; Morales-Quinteros, Luis; Nosten, Francois; Papali, Alfred; Paternoster, Gianluca; Paulus, Frederique (Lectoraat Critical Care); Pisani, Luigi; Prud'homme, Eloi; Ricard, Jean-Damien; Roca, Oriol; Sartini, Chiara; Scaravilli, Vittorio; Schultz, Marcus J.; Sivakorn, Chaisith; Spronk, Peter E.; Sztajnbok, Jaques; Trigui, Youssef; Vollman, Kathleen M.; van der Woude, Margaretha C. E.

Non-intubated patients with acute respiratory failure due to COVID-19 could benefit from awake proning. Awake proning is an attractive intervention in settings with limited resources, as it comes with no additional costs. However, awake proning remains poorly used probably because of unfamiliarity and …

2021AlgemeenArtikel

High prevalence of malnutrition in internal medicine wards - a multicentre ANUMEDI study

Marinho, Ricardo; Pessoa, Ana; Lopes, Marta; Rosinhas, J.; Pinho, João Pedro; Silveira, Joana; Amado, Ana; Gomes Silva, Sandra; Oliveira, Bruno; Marinho, Anibal; Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing)

Background: Disease-related malnutrition is a significant problem in hospitalized patients, with high prevalence rates depending on the studied population. Internal Medicine wards are the backbone of the hospital setting. However, prevalence and determinants of malnutrition in these patients remain unclear. …

2020-06-01AlgemeenArtikel

Reporting incidents involving the use of advanced medical technologies by nurses in home care

Haken, I. (Ingrid) ten (Phd); Ben Allouch, S. (Somaya) (Lector); Harten, W.H. (Wim) van (Professor)

Background Advanced medical technologies (AMTs), such as respiratory support or suction devices, are increasingly used in home settings and incidents may well result in patient harm. Information about risks and incidents can contribute to improved patient safety, provided that those are reported …

2020-06-01AlgemeenArtikel

Focus group study on mechanical in- exsufflation in invasively ventilated intensive care patients

Stilma, W. (Faculteit Gezondheid)

Introduction: Few data described practicalities of using mechanical insufflation-exsufflation (MI-E) for invasively ventilated ICU patients and evidence for benefit of their use is lacking. Aim and objective: To identify barriers and facilitators to use MI-E devices in invasively ventilated ICU patients, …

2020-02-13AlgemeenArtikel

Doxycycline for exacerbations of chronic obstructive pulmonary disease in outpatients

van Velzen, Patricia; ter Riet, Gerben (Faculteit Gezondheid); Brinkman, Paul; Sterk, Peter J; Prins, Jan M

No clinical characteristics, particularly not sputum characteristics, can guide antibiotic prescription in patients with mild to severe COPD exacerbations

2020AlgemeenArtikel

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