RATIONALE: To date, causal therapy is potentially available for GRIN2B-related neurodevelopmental disorder (NDD) due to loss-of-function (LoF) variants in GRIN2B, resulting in dysfunction of the GluN2B subunit-containing N-methyl-d-aspartate receptor (NMDAR). Recently, in vitro experiments showed that …

Een te grote toename van belasting, overtraining en ondertraining vergroten allen de kans de op blessures. Door het monitoren van externe belasting kan inzicht worden gegeven wanneer de kans op een blessure groter is en kan dit worden voorkomen. Wanneer een speler geblesseerd raakt moet deze speler gaan …

Early mobilisation after abdominal surgery is necessary to avoid complications and increase recovery. However, due to a variety of factors, failure of early mobilisation is seen in clinical practice. The aim of this study is to investigate the perspectives of nurses and patients of the Haaglanden Medical …

Purpose. We aimed to evaluate the potential for implementing exercise interventions for patients with breast cancer in the Netherlands, based on findings of the Dutch randomized controlled trials in this population. Methods. We evaluated the implementation of four Dutch exercise trials retrospectively, …

Dit hoofdstuk beschrijft het PEOP-model en het bijbehorende PEOP OT-procesmodel. Het PEOP-model benadrukt de noodzaak van het competent zijn in het dagelijks handelen om participatie en welzijn mogelijk te maken. In het PEOP-model zijn zowel de persoonlijke als de omgevingsfactoren belangrijk in het …

Background Critically ill patients are subject to severe skeletal muscle wasting during intensive care unit (ICU) stay, resulting in impaired short- and long-term functional outcomes and health-related quality of life. Increased protein provision may improve functional outcomes in ICU patients by attenuating …

The following paper presents a methodology we developed for addressing the case of a multi-modal network to be implemented in the future. The methodology is based on a simulation approach and presents some characteristics that make a challenge to be verified and validated. To overcome this limitation, …

This is a print publication of the inaugural lecture of Research Professor (Lector) Patricia de Vries at the Gerrit Rietveld Academie, in Amsterdam. In this lecture, she elaborated on the research area of her research group Art & Spatial Praxis. The research group Art & Spatial Praxis focuses on artistic …