Background Young adulthood is a challenging period for people with diabetes mellitus type 1 (T1DM) as they are facing multiple life transitions while managing a demanding disease. This poses a risk for impaired health-related quality of life (HRQOL). We assessed HRQOL in a cohort of young adults with …

Development of novel testing strategies to detect adverse human health effects is of interest to replace in vivo-based drug and chemical safety testing. The aim of the present study was to investigate whether physiologically based kinetic (PBK) modeling-facilitated conversion of in vitro toxicity data …

Systemic sclerosis (SSc) is an autoimmune disease which is characterized by vasculopathy, tissue fibrosis and activation of the innate and adaptive immune system. Clinical features of the disease consists of skin thickening and internal organ involvement. Due to the heterogeneous nature of the disease …

The culture of fear seems to be increasingly embedded in today’s society, especially on highly social unequal countries, such as Brazil. The rise of the “condomínios fechados” (gated communities) on recent years expose how this fear shapes our cities. People are sold by the idea of isolating themselves …

Global climate change is resulting in a wide range of biotic responses, including changes in diel activity and seasonal phenology patterns, range shifts polewards in each hemisphere and/or to higher elevations, and altered intensity and frequency of interactions between species in ecosystems.Oak (Thaumetopoea …

OBJECTIVE: Language development is important for children's success in life. Therefore, language is monitored by child health care professionals and parents, but a uniform set of milestones in language development is lacking. Our aim was to identify a set of clear and distinctive milestones that empirically …

Purpose: Exercise therapy with a focus on muscle strengthening has proven to be effective for the management of knee osteoarthritis (OA). Yet it is not known whether high-intensity resistance training (RT) is more effective in improving upper leg muscle strength and physical performance than low-intensity …

Purpose: Instability of the knee joint is reported by a majority (>65%) of patients with knee osteoarthritis (KOA) and is hypothesized to play a crucial role in the initiation and progression of KOA. A generally accepted objective metric of knee joint stability is lacking, making development of diagnostics …

Renewing agricultural grasslands for improved yields and forage quality generally involves eliminating standing vegetation with herbicides, ploughing and reseeding. However, grassland renewal may negatively affect soil quality and related ecosystem services. On clay soil in the north of the Netherlands, …

Horizontal axis wind turbines (HAWTs) experience three-dimensional rotational and unsteady aerodynamic phenomena at the rotor blades sections. These highly unsteady three-dimensional effects have a dramatic impact on the aerodynamic load distributions on the blades, in particular, when they occur at …