OBJECTIVE: Evaluate clinical outcome of early cyclic intravenous pamidronate treatment in children with moderate-to-severe osteogenesis imperfecta (OI), commenced before three years of age. METHODS: A retrospective review of 17 patients with moderate-to-severe OI. Development, anthropometry, fracture …

Harbour porpoises (Phocoena phocoena) are the smallest cetaceans in the North Sea. They have recovered from being rare to nowadays being present throughout the year in numbers reaching to 80 000 in the Dutch sector or the North Sea. The only area where studies were conducted prior to the disappearance …

The Stuwwal Nijmegen provides special beauty with landscape contrasts such as the contrast between high and low. The complex underground provides a great diversity in flora and fauna. This extraordinary beauty is in danger of being lost due to increasing climate change. The hilly landscape extends to …

In this dissertation, the European Commission's selection process of policy instruments to tackle climate change has been reviewed, with the main focus on understanding what internal factors have influenced the Commission in this process and how this has led to the implementation of soft policy instruments. …

This article describes experiences with a qualitative research project into teachers’ learning from innovating their own educational practices. Decades of New Public Management (NPM) in the Netherlands, with its top-down and businesslike approach to areas of public interest, obscured the learning and …

In this essay Chris van der Heijden (Dat nooit meer [Never Again]) answers his critics. He accepts in general what Bob Moore says, although his criticism is rather abstract. He does agree partly with Koes Aerts, but not on some crucial points – for example the method. Van der Heijden doesn’t agree at …

Rian de Waal (1958-2011) has written a book about the piano, and how the development of piano playing has been very much dependent upon musicians who were able to cross borders. In Metamorphoses, the Art of the Virtuoso Piano Transcription, De Waal takes us on a journey through the capricious history …

Het ontwerpondersteunend onderzoek is gericht op het vinden van handvatten voor de uitwerking van het masterplan. Het masterplan is gemaakt voor de omgeving Kampen en Zwolle, gelegen in de IJssel-Vechtdelta. Nederzettingen in de IJssel-Vechtdelta hebben tot op heden niet altijd gebruik gemaakt van hun …

This paper presents a multidisciplinary conceptual framework which proposes the symbolic-based eco-genetic process for dealing with complex patterns characterized by multilevel and fuzzy territorial governance, and interrelatedness between the physical world and the symbolic and socially-culturally constructed …

This article teaches that, like today in the context of cyber security, various nations came up with divergent approaches and responses at the tactical, operational and strategic levels. The explanation given lies in the fact that - apart from the common security setting and available technology - policy …