Background: Drug resistance is a major problem in ovarian cancer. Triggering apoptosis using death ligands such as tumour necrosis factor-related apoptosis inducing ligand (TRAIL) might overcome chemoresistance. Methods: We investigated whether acquired cisplatin resistance affects sensitivity to recombinant …

The invention relates to a novel class of [1,4]-benzodiazepine derivatives, processes for their preparation, intermediates usable in these processes, and pharmaceutical compositions containing the compounds. Other aspects of the invention are directed to the use of said [1,4]-benzodiazepine derivatives …

The objective of this study was to perform a systematic review on training outcomes influencing physical fitness, activity of daily living performance, and quality-of-life in institutionalized older people. We reviewed 27 studies on older people (age, ≥70 yrs) in long-term care facilities and nursing …

In this report, the topic of loyalty programs in a franchise business model will be discussed with the analysis focusing on the situation at Mexx International. Currently, there is one centrally run program, Mexx Connect, in the company's most important markets in Western Europe. However, in Region 3 …

Aanleiding Kanker is na hart- en vaatziekten de tweede doodsoorzaak in Nederland. Kanker en de behandeling hiervan hebben een tal van negatieve bijwerkingen. Vermoeidheid is de meestvoorkomende bijwerking van de kankerpopulatie na chemotherapie en heeft een grote invloed op kwaliteit van leven. Het is …

Het bedrijf Phytonics heeft het natuurlijke gezondheidsproduct, ‘‘Gluco balance’’ ontwikkeld, dat paarden met symptomen van insulineresistentie ondersteunt. Voor dit product wordt geclaimd, dat het de gevoeligheid van de insuline cel receptoren verbetert, en dat hiermee de insuline- en glucoseconcentraties …

The amount of used antibiotics is a large problem concerning human health. More and more resistance has occurred during the last years. The Dutch government has announced lowering of used antibiotics in the Netherlands has to be reached. The amount of used antibiotics can be described in several ways. …

Within change literature, pace and frequency of organizational change are reoccurring topics. The pace is experienced as high and the frequency of change within organizations appears to be growing exponentially. This lead to study to more extent ‘change fatigue’ that already received attention in both …