Glucocorticoids (GCs), such as prednisolone (PRED), are widely prescribed anti-inflammatory drugs, but their use may induce glucose intolerance and diabetes. GC-induced beta cell dysfunction contributes to these diabetogenic effects through mechanisms that remain to be elucidated. In this study, we hypothesized …

Microencapsulation of cells is a promising approach to prevent rejection in the absence of immunosuppression. Clinical application, however, is hampered by insufficient insight in factors influencing biocompatibility of the capsules in humans. In the present study we exposed alginate-based capsules prepared …

This research is conducted for the Food and Agriculture Research and Advisory department at Rabobank North and is designated for internal use only. The research is constructed from desk research and field research by means of interview responses from participants active in various parts of the California …

There are many Cameroonian graduates in the Netherlands who have acquired great competencies in different professional fields but have decided to stay and work abroad. Some that were interviewed during field work said there are no jobs in Cameroon, so they prefer to live abroad where graduates have more …

Background: Drug resistance is a major problem in ovarian cancer. Triggering apoptosis using death ligands such as tumour necrosis factor-related apoptosis inducing ligand (TRAIL) might overcome chemoresistance. Methods: We investigated whether acquired cisplatin resistance affects sensitivity to recombinant …

Social media have become an important element of modern society in a short period of time. Social media are online tools to connect people; it implies the development of publication to conversation and from sending to dialogue (Social Media Update 2010, 2010, p.2). It is important to keep in mind that …

Exposure data available to developers of earthquake loss models are often very crudely aggregated spatially, and in such cases very considerable effort can be required to refine the geographical resolution of the building stock inventory. The influence of the geographical resolution of the exposure data …

During the past decade there has been a huge increase in the number of internet users, this has among other things resulted in a high growth of online networks. Many network providers are trying to attract new members, the competition is fierce. Therefore the purpose of this study was to investigate …

In deze casestudy leest u hoe de dubbele diagnose (dd) cliënt te werk gaat in zijn of haar behandeling. Ik richt mij op de klinisch dynamische behandelgroep. De dd cliënten uit deze groep hebben voornamelijk een hoofddiagnose op de as II (persoonlijkheidsstoornissen) in combinatie met een middelen-afhankelijkheids-problematiek. …

The objective of this research is to analyse the German equestrianism print and online media by assessing quality, characteristics and focus groups of each medium in order to find the suitable media that go in line with Pavo's marketing communication strategy and reach their target group effectively …