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The impact of nutrition on the lives of patients with digestive cancers: a position paper.

M. Vitaloni; R. Caccialanza; P Ravasco; A. Carrato; A. Kapala; D. Constantinides; E. Backman; D. Chuter; C. Santangelo; Z. Maravic; Marian de van der Schueren

Nutritional intervention is an essential part of cancer treatments. Research and clinical evidence in cancer have shown that nutritional support can reduce length of hospitalisation, diminish treatment-related toxicity, and improve nutrient intake, quality of life, and physical function. Nutritional …

2022AlgemeenArtikel

Repeated-Dose Toxicity, Biodistribution, and Shedding Assessments With a ChAd155 Respiratory Syncytial Virus Vaccine Candidate Evaluated in Rabbits and Rats

AH Stokes; C Planty; J Pion; P Ancian; A Rogue; C Bansard; J Silvano; D Papineau; N Ben Abdeljelil; G Maruggi; HF Song; C Spickler; K Blouin; G Dubois; LA Rodriguez; J Baumeister; AM Steff; E Destexhe

Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections (LRTI) in infants, and toddlers and vaccines are not yet available. A pediatric RSV vaccine (ChAd155-RSV) is being developed to protect infants against RSV disease. The ChAd155-RSV vaccine consists of a recombinant …

2022AlgemeenArtikel

An integrated image of the effect of multiple stressors (temperature rise & plastic chemical pollution) on the harpacticoid copepod Nitokra spinipes

Els de Vreede (Student); Bram Verkruysse (Docent); Ana Catarino (Begeleider)

Since the Industrial Revolution, human activity has reinforced climate change to alarming rates and has introduced new stressors such as plastic pollution to the environment. Currently, 4.8 - 12.7 million tons of plastic litters enter the oceans every year. Globally alternatives to replace synthetic-based …

2021-06-30Natuur & LandbouwBachelor

Integrating in vitro data and physiologically based kinetic modeling-facilitated reverse dosimetry to predict human cardiotoxicity of methadone

Shi, M.; Bouwmeester, H.; Rietjens, I.M.C.M.; Strikwold, M. (Associate Lector)

Development of novel testing strategies to detect adverse human health effects is of interest to replace in vivo-based drug and chemical safety testing. The aim of the present study was to investigate whether physiologically based kinetic (PBK) modeling-facilitated conversion of in vitro toxicity data …

2020-05-04GezondheidArtikel

Low muscle mass is associated with early termination of chemotherapy related to toxicity in patients with head and neck cancer

Sealy, Martine J. (Healthy Ageing, Allied Health Care And Nursing); Dechaphunkul, Tanadech; van der Schans, Cees P. (Healthy Ageing, Allied Health Care And Nursing); Krijnen, Wim P (Statistical Techniques For Applied Research); Roodenburg, Jan L. N.; Walker, John; Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing); Baracos, Vickie E.

BACKGROUND & AIMS: We studied whether low pre-treatment muscle mass, measured with CT at thoracic (T4) or lumbar level (L3) associates with early termination of chemotherapy related to toxicity in head and neck cancer (HNC) patients. METHODS: This was a retrospective chart and image review. Adult HNC …

2020-02AlgemeenArtikel

The effect of nutritional counseling on muscle mass and treatment outcome in patients with metastatic colorectal cancer undergoing chemotherapy: A randomized controlled trial

A. van der Werf; J.A.E. Langius; A Beeker; AJ ten Tije; AJ Vulink; A Haringhuizen; J Berkhof; HJ van der Vliet; H.M.W. Verheul; Marian de van der Schueren

Background & aims: A low muscle mass before start of treatment and loss of muscle mass during chemotherapy is related to adverse outcomes in patients with cancer. In this randomized controlled trial, the effect of nutritional counseling on change in muscle mass and treatment outcome in patients with …

2020AlgemeenArtikel

Integrating physiologically based kinetic (PBK) and Monte Carlo modelling to predict inter-individual and inter-ethnic variation in bioactivation and liver toxicity of lasiocarpine

Ning, J.; Rietjens, I.M.C.M.; Strikwold, M. (Lector)

The aim of the present study was to predict the effect of inter-individual and inter-ethnic human kinetic variation on the sensitivity towards acute liver toxicity of lasiocarpine in the Chinese and the Caucasian population, and to derive chemical specific adjustment factors (CSAFs) by integrating variation …

2019-09-11GezondheidArtikel

Validation of the short-chronic early life stage fish toxicity test

Sean Teng (Student); Emma McAteer (Begeleider); Klaas Kaag (Begeleider)

In light of recent developments of the onboard ballast water treatment, WMR has developed a new protocol for the assessment of ecotoxicological effects and aims to use it as a standardised test. This study looks into the validation of this short-chronic ELS fish toxicity test, by use of the embryonic …

2019-07-02Techniek; …Bachelor

Callitriche cophocarpa as a phytoremediator to remove toxic arsenic form the environment

Breet, M. (Student); Pouw-Nijlunsing, A.

Water pollution by arsenic (As) is a problem in many areas of the world for both ecology and humans. To remove arsenic from surface water an environmental-friendly method called phytoremediation could be used. This method includes the usage of plants to accumulate toxins from any environmental soil, …

2019-03-18Natuur & LandbouwBachelor

Use of an in vitro–in silico testing strategy to predict inter-species and inter-ethnic human differences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliine

Ning, J.; Chen, L.; Strikwold, M. (Lector)

Lasiocarpine and riddelliine are pyrrolizidine alkaloids (PAs) known to cause liver toxicity. The aim of this study was to predict the inter-species and inter-ethnic human differences in acute liver toxicity of lasiocarpine and riddelliine using physiologically based kinetic (PBK) modelling based reverse …

2019-01-19GezondheidArtikel

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