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Does muscle mass measured with Computed Tomography analysis differ in patients with different types of cancer?

Sealy, Martine (Malnutrition And Healthy Ageing); Van den Broeck, Jona; Brussaard, Carola; Scafoglieri, Aldo; Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing)

Rationale: Patients with cancer of the upper gastrointestinal tract or lung are more likely to present with malnutrition at diagnosis than, for instance, patients with melanoma. Low muscle mass is an indicator of malnutrition and can be determined by computed tomography (CT) analysis of the skeletal …

2021-12-01AlgemeenConferentiebijdrage

Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells

Lagerwaard, B.; Hoek, M.D. van der (Phd); Hoeks, J.; Grevendonk, L.; Nieuwenhuizen, A.G.; Keijer, J.; Boer, V.C.J. de

Protein acylation via metabolic acyl-CoA intermediates provides a link between cellular metabolism and protein functionality. A process in which acetyl-CoA and acetylation are fine-tuned is during myogenic differentiation. However, the roles of other protein acylations remain unknown. Protein propionylation …

2021-04-28GezondheidArtikel

The effects of whey protein suppletion after strength training to promote muscle protein synthesis in the elderly aged 65 or older: a systematic review

Slemmer, Tarquin (Student); Engberink, Mariëlle; Tieland, Michael

Background: Society ages, and the incidence of physical limitations and frailty is increasing. For frail older adults, these limitations will lead to more assistance in daily living activities. A significant cause of physical limitation and frailty is sarcopenia, age-related loss of skeletal muscle mass, …

2021GezondheidBachelor

Cancer cachexia: an overview of diagnostic criteria and therapeutic approaches for the accredited practicing dietitian

Barbara van der Meij; L Teleni; AL McCarthy; EA Isenring

Background: Cancer cachexia (CC) is a multifactorial syndrome characterised by ongoing skeletal muscle loss that leads to progressive functional impairment driven by reduced food intake and abnormal metabolism. Despite the traditional use of non-volitional weight loss as the primary marker of CC, there …

2021AlgemeenArtikel

Presence or Absence of Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease is Associated With Distinct Phenotypes

C.L. Cruthirds; Barbara van der Meij; A. Wierzchowska-McNew; N.E.P. Deutz; M.P.K.J. Engelen

2021AlgemeenArtikel

Blended home-based exercise and dietary protein in community-dwelling older adults: a cluster randomized controlled trial

van den Helder, Jantine (Centre Of Expertise Urban Vitality); Mehra, Sumit; van Dronkelaar, Carliene (Centre Of Expertise Urban Vitality); ter Riet, Gerben; Tieland, Michael (Centre Of Expertise Urban Vitality); Visser, Bart (Centre Of Expertise Urban Vitality); Kröse, Ben J.A.; Engelbert, Raoul H.H. (Centre Of Expertise Urban Vitality); Weijs, Peter J.M. (Centre Of Expertise Urban Vitality)

Background: Effective and sustainable interventions are needed to counteract the decline in physical function and sarcopenia in the growing aging population. The aim of this study was to determine the 6 and 12 month effectiveness of blended (e-health + coaching) home-based exercise and a dietary protein …

2020-12AlgemeenArtikel

Obese older Type 2 Diabetes Mellitus patients with muscle insulin resistance benefit from an enriched protein drink during combined lifestyle intervention

Pasman, Wilrike J.; Memelink, Robert G. (Centre Of Expertise Urban Vitality); de Vogel-Van den Bosch, Johan; Begieneman, Mark P.V.; van den Brink, Willem J.; Weijs, Peter J.M. (Centre Of Expertise Urban Vitality); Wopereis, Suzan

(1) Background: Recent research showed that subtypes of patients with type 2 diabetes may differ in response to lifestyle interventions based on their organ-specific insulin resistance (IR). (2) Methods: 123 Subjects with type 2 diabetes were randomized into 13-week lifestyle intervention, receiving …

2020-09-29AlgemeenArtikel

Early high protein intake and mortality in critically ill ICU patients with low skeletal muscle area and -density

Looijaard, Wilhelmus G.P.M.; Dekker, Ingeborg M.; Beishuizen, Albertus; Girbes, Armand R.J.; Oudemans-van Straaten, Heleen M.; Weijs, Peter J.M.

Background & aims: Optimal nutritional support during the acute phase of critical illness remains controversial. We hypothesized that patients with low skeletal muscle area and -density may specifically benefit from early high protein intake. Aim of the present study was to determine the association …

2020-07-01AlgemeenArtikel

Identifying critically ill patients with low muscle mass

Looijaard, Willem G.P.M.; Stapel, Sandra N.; Dekker, Ingeborg M.; Rusticus, Hanna; Remmelzwaal, Sharon; Girbes, Armand R.J.; Weijs, Peter J.M.; Oudemans-van Straaten, Heleen M.

Background & aims: Low muscle mass and -quality on ICU admission, as assessed by muscle area and -density on CT-scanning at lumbar level 3 (L3), are associated with increased mortality. However, CT-scan analysis is not feasible for standard care. Bioelectrical impedance analysis (BIA) assesses body …

2020-06AlgemeenArtikel

Low muscle mass is associated with early termination of chemotherapy related to toxicity in patients with head and neck cancer

Sealy, Martine J. (Healthy Ageing, Allied Health Care And Nursing); Dechaphunkul, Tanadech; van der Schans, Cees P. (Healthy Ageing, Allied Health Care And Nursing); Krijnen, Wim P (Statistical Techniques For Applied Research); Roodenburg, Jan L. N.; Walker, John; Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing); Baracos, Vickie E.

BACKGROUND & AIMS: We studied whether low pre-treatment muscle mass, measured with CT at thoracic (T4) or lumbar level (L3) associates with early termination of chemotherapy related to toxicity in head and neck cancer (HNC) patients. METHODS: This was a retrospective chart and image review. Adult HNC …

2020-02AlgemeenArtikel

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