Om in de komende decennia te kunnen voldoen aan de ruimtevraag van circulaire bedrijven is het belangrijk dat circulaire economie hoger op de agenda van het omgevingsbeleid komt. Anders dreigt de ontluikende circulaire economie vast te lopen door ruimtegebrek en onomkeerbare keuzes, bleek tijdens een …

Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems. Clinical application of GGA in AF is limited, due to low systemic concentrations owing to the hydrophobic character …

According to the "membrane sensor" hypothesis, the membrane's physical properties and microdomain organization play an initiating role in the heat shock response. Clinical conditions such as cancer, diabetes and neurodegenerative diseases are all coupled with specific changes in the physical state and …

Atrial fibrillation (AF) is the most common clinical tachyarrhythmia associated with significant morbidity and mortality and is expected to affect approximately 30 million North Americans and Europeans by 2050. AF is a persistent disease, caused by progressive, often age-related, derailment of proteostasis …