5% to 10% of all cancers are linked to gene mutations inherited from parents. The most common gene related to hereditary cancer is the p53 gene. It is a crucial tumor suppressor. However, the mutated gene is commonly inherited from one generation to another one. The functions of p53 resume to the activation …

Background: Lung fibroblasts are implicated in abnormal tissue repair in chronic obstructive pulmonary disease (COPD). The exact mechanisms are unknown and comprehensive analysis comparing COPD- and control fibroblasts is lacking. Aim: To gain insight in the role of lung fibroblasts in COPD pathology …

1. Topics of interest were defined following a risk based approach. 2. Study priorities were set based on knowledge gaps in current practices, but they were conditioned by pragmatic limitations. 3. Focus topics : failure modes, detection and monitoring and repairs. 4. Serious failures can occur in sections …

Dat groei gepaard gaat met ontwrichting is niks nieuws aan de horizon. Niet elke organisatie is klaar om in korte tijd snel te groeien en groeit hierdoor letterlijk uit haar jasje! Zo ook bij Gallagher Europe die in een relatief korte tijd snel is gegroeid. Zo’n groei brengt aspecten met zich mee die …

Het is geen toeval dat de Repair Cafés populair zijn en dat YouTube video’s met tips voor het repareren van spullen vaak worden bekeken. Repareren scheelt je natuurlijk in je portemonnee, het geeft voldoening en trots, zo laten bijvoorbeeld de vrolijke video’s van Rob Hoevenaars zien. Daar zit ook een …

Closing the loop of products and materials in Product Service Systems (PSS) can be approached by designers in several ways. One promising strategy is to invoke a greater sense of ownership of the products and materials that are used within a PSS. To develop and evaluate a design tool in the context of …

Engineers design levees without taking into account animal activity. But in reality: *Levees attract burrowing animals *Many of them are protected (e.g. beavers) *It is not always easy to detect burrows and remove them Topics of interest are: 1. Eco engineering approaches for deterrence of animals …

This book is both a short introduction to the recent developments, challenges and opportunities in Aviation Maintenance, Repair and Overhaul(MRO), and at the same time, a presentation of the research focal areas and the key waypoints towards smarter and more sustainable MRO. Innovation and integration …

Export shipments arriving late at the freight building of KLM Cargo at Schiphol Airport is a trigger to deviations in the standard acceptance process. These Late Shows are currently handled ad-hoc making it difficult to plan and predict these events. In addition, shipments arriving on time is currently …

According to John Braithwaite (2004), a distinguished criminology professor at the Australian National University, restorative justice is a process where all stakeholders affected by an injustice have an opportunity to discuss how they have been affected by the injustice and to decide what should be …