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GMP Compliant Synthesis of [18F]Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2

van der Hoek, Sjoukje; Antunes, Inês F.; Attia, Khaled A.; Jacquet, Olivier; Heeres, André (Biobased Chemistry & Refinery); Bulthuis, Marian; Zijlma, Rolf; Boersma, Hendrikus H.; van Goor, Harry; Visser, Ton J.; Heerspink, Hiddo J. L.; Elsinga, Philip H.; Stevens, Jasper

Inhibition of the sodium–glucose cotransporter 2 (SGLT2) by canagliflozin in type 2 diabetes mellitus results in large between-patient variability in clinical response. To better understand this variability, the positron emission tomography (PET) tracer [18F]canagliflozin was developed via a Cu-mediated …

2021-11-08AlgemeenArtikel

The effect of a multidisciplinary lifestyle program for patients with rheumatoid arthritis, an increased risk for rheumatoid arthritis or with metabolic syndrome-associated osteoarthritis

Walrabenstein, Wendy; van der Leeden, Marike; Weijs, Peter (Lectoraat Voeding En Beweging); van Middendorp, Henriët; Wagenaar, Carlijn; van Dongen, Johanna Maria; Nieuwdorp, Max; de Jonge, Catharina Sophia; van Boheemen, Laurette; van Schaardenburg, Dirkjan

Low-grade inflammation and metabolic syndrome are seen in many chronic diseases, including rheumatoid arthritis (RA) and osteoarthritis (OA). Lifestyle interventions which combine different non-pharmacological therapies have shown synergizing effects in improving outcomes in patients with other chronic …

2021-10-18AlgemeenArtikel

Development of SARS-COV-2 inhibitors by fragment based drug discovery

Anne van der Sluis (Student)

The coronavirus disease-19 (COVID-19) pandemic still poses serious threats to global public health. Therefore, the scientific community is desperately looking for suitable vaccines and pharmacological treatment options. This thesis completes the internship at Specs Compound Handling BV and describes …

2021-06-16GezondheidBachelor

Are active interventions effective compared to passive non-pharmacological interventions in the treatment of sensory and motor symptoms and improving quality of life in patients diagnosed with chemotherapyinduced peripheral neuropathy?

Susan Schnitter (Student); Caspar Mijlius (Begeleider)

Cancer was diagnosed in 19.292.789 patients worldwide in 2020, depending on the type of cancer treatment may involve chemotherapy. If a neurotoxic agent is used, patients can develop chemotherapy-induced peripheral neuropathy (CIPN) affecting 68% of patients within the first months of treatment. CIPN …

2021-04-17GezondheidBachelor

Healthcare needs, expectations, utilization, and experienced treatment effects in patients with hereditary spastic paraplegia: a web-based survey in the Netherlands

Hans Kerstens; B.J.H. van Lith; M.J. Nijkrake; Bert de Swart; LAC van den Bemd; RJEM Smeets; F Klemens; BPC van de Warrenburg; P.J. van der Wees; A.C.H. Geurts

Background We aimed to identify healthcare needs, expectations, utilization, and the experienced treatment effects in a population of Dutch patients with hereditary spastic paraplegia (HSP). Methods We distributed an online questionnaire among 194 adult persons with HSP in the Netherlands, of which 166 …

2021AlgemeenArtikel

Opening the black box of non-pharmacological care in systemic sclerosis: a cross-sectional online survey of Dutch health professionals

Juliane Stöcker; M.C. Vonk; F.H.C. van den Hoogen; Ria Nijhuis-van der Sanden; J Spierings; Bart Staal; Ton Satink; C.H.M. Ende

2020AlgemeenArtikel

Room for improvement in non-pharmacological systemic sclerosis care?—a cross-sectional online survey of 650 patients

Juliane Stöcker; M.C. Vonk; F.H.C. van den Hoogen; Ria Nijhuis-van der Sanden; Bart Staal; Ton Satink; C.H.M. Ende

2020AlgemeenArtikel

Hypermobility syndrome and Ehlers-Danlos syndrome (hypermobility type): unravelling the concepts of disability during childhood

M.C. Scheper

Disability in children diagnosed with hypermobility syndrome (HMS) and Ehlers-Danlos (hypermobility type: EDS-HT) can vary from mild to very severe. This disability can be of temporary nature but for some may persist and become chronic, eventually leading to disablement. Historically it is believed that …

2019-12-20GezondheidProefschrift

Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis.

A. Correa-Pérez; I. Abraha; A. Cherubini; A. Collinson; D. Dardevet; L.C.P.G.M. de Groot; Marian de van der Schueren; A. Hebestreit; M. Hickson; J. Jaramillo-Hidalgo; I. Lozano-Montoya; D. O'Mahony; R.L. Soiza; M. Visser; D. Volkert; M. Wolters; A.J.C. Jentoft

2019AlgemeenArtikel

Treating phantom limb pain following amputation

Andreas Rothgangel (Lid Lectoraat); Rob Smeets; Susy Braun (Lector); Sandra Beurskens (Lector)

Phantom limb pain following amputation is highly prevalent as it affects up to 80% of amputees. Many amputees suffer from phantom limb pain for many years and experience major limitations in daily routines and quality of life. Conventional pharmacological interventions often have negative side-effects …

2019GezondheidBoek

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