There is now a convergence of two modes of genetic testing, that of testing a few candidate genes at a time based on suspicion of a specific genetic disease, and that of genomic testing, especially when a candidate gene(s) is not suspected or known. Both aim to interpret pathogenicity of identified genetic …

The identification of translation initiation sites (TISs) constitutes an important aspect of sequence-based genome analysis. An erroneous TIS annotation can impair the identification of regulatory elements and N-terminal signal peptides, and also may flaw the determination of descent, for any particular …

Background: Matching and comparing sequence annotations of different reference sequences is vital to genomics research, yet many annotation formats do not specify the reference sequence types or versions used. This makes the integration of annotations from different sources difficult and error prone. Results: …

The architecture of TP 53 , the most frequently mutated gene in human cancer, is more complex than previously thought. Using TP 53 variants as clinical biomarkers to predict response to treatment or patient outcome requires an unequivocal and standardized procedure toward a definitive strategy for the …

De Creatief procestheorie is een waardevolle grondslag gebleken voor de Creatieve Therapie in Nederland. Door diverse ontwikkelingen is de Creatief procestheorie als zodanig minder zichtbaar geworden binnen het onderwijs en de vakliteratuur. Hierdoor heeft de ontwikkeling in zowel verbreding als verdieping …

This publication gives an account of the Public Annotation of Cultural Heritage research project (PACE) conducted at the Crossmedialab. The project was carried out between 1 January 2008 and 31 December 2009, and was funded by the Ministry of Education, Culture, and Science. Three members of the Dutch …

Op 15 oktober 2009 heeft in Zwartsluis de 5de editie van de Gebiedsconferentie Nationaal Landschap IJsseldelta plaatsgevonden. Dit is een verslag van die dag.