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Nailfold capillaroscopy and candidate-biomarker levels in systemic sclerosis-associated pulmonary hypertension

Lemmers, Jacqueline; van Caam, Arjan; Kersten, Brigit E.; van den Ende, Cornelia; Knaapen, Hanneke; van Dijk, Arie; Hagmolen of Ten Have, Wanda; van den Hoogen, Frank; Koenen, Hans J P M; van Leuven, Sander; Alkema, Wynand (Data Science For Life Science & Health); Smeets, Ruben L; Vonk, Madelon C.

Objectives: Pulmonary hypertension is one of the leading causes of death in systemic sclerosis. Early detection and treatment of pulmonary hypertension in systemic sclerosis is crucial. Nailfold capillaroscopy microscopy, vascular autoantibodies AT1R and ETAR, and several candidate-biomarkers have the …

2023-05-22AlgemeenArtikel

Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration

Nollet, Edgar E; Duursma, Inez; Rozenbaum, Anastasiya; Eggelbusch, Moritz; Wüst, Rob C I; Schoonvelde, Stephan A C; Michels, Michelle; Jansen, Mark; van der Wel, Nicole N; Bedi, Kenneth C Jr; Margulies, Kenneth B; Nirschl, Jeff; Kuster, Diederik W D; van der Velden, Jolanda

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitochondrial dysfunction is thought to be a key driver of …

2023-04-01AlgemeenArtikel

Response to: "The use of ultrasound for the estimation of muscle mass: one site fits most?"

Nijholt, Willemke; Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing); Scafoglieri, Aldo; Hobbelen, Hans (Ageing And Allied Health Care); van der Schans, Cees (Healthy Ageing, Allied Health Care And Nursing)

The performance of neural electrodes in physiological fluid, especially in chronic use, is critical for the success of functional electrical stimulation devices. Tips of the Utah electrode arrays (UEAs) were coated with sputtered iridium oxide film (SIROF) and activated iridium oxide film (AIROF) to …

2018-06-01AlgemeenArtikel

Capturing and displaying microscopic images used in medical diagnostics and forensic science using 4K video resolution – an application in higher education

Jan Kuijten (Docent); Ajda Ortac; Hans Maier; Gert de Heer

To analyze, interpret and evaluate microscopic images, used in medical diagnostics and forensic science, video images for educational purposes were made with a very high resolution of 4096 × 2160 pixels (4K), which is four times as many pixels as High-Definition Video (1920 × 1080 pixels). The unprecedented …

2015-05-31TechniekArtikel

Protein expression of UCP3 differs between human type 1, type 2a and type 2 fibers.

G. Schaart; M.K.C. Hesselink; C.F.P. Kornips; P. Schrauwen; W.H.M. Saris; L.B. Borghouts (Lector); L.J. Slieker; K.W. Sloop; H.A. Keizer

Muscle fiber-type specific expression of UCP3-protein is reported here for the firts time, using immunofluorescence microscopy

2001AlgemeenArtikel

GLUT-4 expression is not consistently higher in type 1 than type 2 fibres of rat and human vastus lateralis muscles: an immunohistochemical study.

L.B. Borghouts (Lector); M.K.C. Hesselink; G. Schaart; H.A. Keizer

Immunofluorescence microscopy in this study shows that GLUT-4 protein expression is fibre-type specific within a muscle. It is postulated that both fibre-type-dependent and fibre-type-independent factors affect GLUT-4 expression.

2000AlgemeenArtikel

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