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Phase II of the DiAgRaMs project

Smelt, Maaike

2018-01-18GezondheidConferentiebijdrage

Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model

Marlotte M. Vonk (Onderzoeker); Mara A.P. Diks (Onderzoeker); Laura Wagenaar (Onderzoeker); J.J. Smit (Onderzoeker); Raymond Pieters (Lector); Johan Garssen (Onderzoeker); Betty C.A.M. van Esch (Onderzoeker); Léon M.J. Knippels (Onderzoeker)

From teh UU repository: "Background: Oral immunotherapy (OIT) is a promising therapeutic approach to treat food allergic patients. However, there are some concerns regarding its safety and long-term efficacy. The use of non-digestible oligosaccharides might improve OIT efficacy since they are known to …

2017GezondheidArtikel

Earlier Detection of Hepatitis C Virus Infection Through Routine Hepatitis C Virus Antibody Screening of Human Immunodeficiency Virus-Positive Men Who Have Sex With Men Attending A Sexually Transmitted Infection Outpatient Clinic: A Longitudinal Study

Martijn van Rooijen (Onderzoeker); Titia Heijman (Onderzoeker); Nynke de Vrieze (Onderzoeker); Anouk Urbanus (Onderzoeker); Arjen Speksnijder (Onderzoeker); Petra van Leeuwen (Onderzoeker); Henri de Vries (Onderzoeker); Maria Prins (Onderzoeker)

Background In 2007, routine hepatitis C virus (HCV) antibody testing was introduced for men who have sex with men (MSM) with a human immunodeficiency virus (HIV)-positive or unknown status attending a Dutch sexually transmitted infection (STI) outpatient clinic. We evaluated whether this screening resulted …

2016-09-01Natuur & LandbouwArtikel

Impaired glucose tolerance in rat islet isograft recipients after cytomegalovirus infection

Smelt, M.J.; de Haan, B.J.; Faas, M.M.; de Haan, A.; de Vos, P.

2013-02AlgemeenArtikel

Recent developments in basophil research

van Beek, A A; Knol, E F; de Vos, P; Smelt, M J; Savelkoul, H F J; van Neerven, R J J

Basophils account for only 0.1-1% of all peripheral blood leukocytes. They were considered to be a redundant cell type for a long time. However, several findings show a non-redundant role for basophils in type 2 T-helper cell (Th2) immune responses in helminth infections, allergy and autoimmunity. Both …

2012-08-30AlgemeenArtikel

Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

Smeets, Ruben L; Fleuren, Wilco W M; He, Xuehui; Vink, Paul M; Wijnands, Frank; Gorecka, Monika; Klop, Henri; Bauerschmidt, Sussane; Garritsen, Anja; Koenen, Hans J P M; Joosten, Irma; Boots, Annemieke M H; Alkema, Wynand (Data Science For Life Science & Health)

BACKGROUND: T lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into Th1, Th2, Th17 or iTreg phenotypes, depending on environmental co-stimulatory signals. To identify genes and pathways involved in differentiation of Jurkat T cells towards Th1 and Th2 subtypes we performed …

2012-03-14AlgemeenArtikel

Structural surface changes and inflammatory responses against alginate-based microcapsules after exposure to human peritoneal fluid

de Haan, Bart J; Rossi, Alessandra; Faas, Marijke M; Smelt, Maaike J; Sonvico, Fabio; Colombo, Paolo; de Vos, Paul

Microencapsulation of cells is a promising approach to prevent rejection in the absence of immunosuppression. Clinical application, however, is hampered by insufficient insight in factors influencing biocompatibility of the capsules in humans. In the present study we exposed alginate-based capsules prepared …

2011-09-01AlgemeenArtikel

The role of nasal carriage in Staphylococcus aureus burn wound colonization

Kooistra-Smid, Mirjam; Nieuwenhuis, Marianne (Functional Recovery And Quality Of Life After Burns); Van Belkum, Alex; Verbrugh, Henri

Thermal injury destroys the physical skin barrier that normally prevents invasion of microorganisms. This and concomitant depression of local and systemic host cellular and humoral immune responses are important factors that contribute to colonization and infection of the burn wound. One of the most …

2009-10-01AlgemeenArtikel

Transcriptional profiling reveals complex regulation of the monocyte IL-1 beta system by IL-13

Scotton, Chris J; Martinez, Fernando O; Smelt, Maaike J; Sironi, Marina; Locati, Massimo; Mantovani, Alberto; Sozzani, Silvano

IL-4 and IL-13 are prototypic Th2 cytokines that generate an “alternatively activated” phenotype in macrophages. We used high-density oligonucleotide microarrays to investigate the transcriptional profile induced in human monocytes by IL-13. After 8-h stimulation with IL-13, 142 genes were regulated …

2005-01-15AlgemeenArtikel

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