Basophils account for only 0.1-1% of all peripheral blood leukocytes. They were considered to be a redundant cell type for a long time. However, several findings show a non-redundant role for basophils in type 2 T-helper cell (Th2) immune responses in helminth infections, allergy and autoimmunity. Both …

BACKGROUND: T lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into Th1, Th2, Th17 or iTreg phenotypes, depending on environmental co-stimulatory signals. To identify genes and pathways involved in differentiation of Jurkat T cells towards Th1 and Th2 subtypes we performed …

Deze scriptie bespreekt de rol van Sialoadhesin op macrofagen in het Guillain-Barré syndroom geinduceerd door Campylobacter jejuni. Sialoadhesin is een receptor gevonden op macrofagen welke mogelijk een rol speelt in de ontwikkeling van Guillain-Barré. Een neuromusculaire ziekte, waarbij verlamming van …