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Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration

Nollet, Edgar E; Duursma, Inez; Rozenbaum, Anastasiya; Eggelbusch, Moritz; Wüst, Rob C I; Schoonvelde, Stephan A C; Michels, Michelle; Jansen, Mark; van der Wel, Nicole N; Bedi, Kenneth C Jr; Margulies, Kenneth B; Nirschl, Jeff; Kuster, Diederik W D; van der Velden, Jolanda

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitochondrial dysfunction is thought to be a key driver of …

2023-04-01AlgemeenArtikel

Skeletal muscle alterations in patients with acute Covid-19 and post-acute sequelae of Covid-19

Soares, Madu N.; Eggelbusch, Moritz; Naddaf, Elie; Gerrits, Karin H. L.; van der Schaaf, Marike (Lectoraat Revalidatie In De Acute Zorg); van den Borst, Bram; Wiersinga, W. Joost; van Vugt, Michele; Weijs, Peter J.M. (Lectoraat Voeding En Beweging); Murray, Andrew J.; Wüst, Rob C.I.

Skeletal muscle-related symptoms are common in both acute coronavirus disease (Covid)-19 and post-acute sequelae of Covid-19 (PASC). In this narrative review, we discuss cellular and molecular pathways that are affected and consider these in regard to skeletal muscle involvement in other conditions, …

2022-02AlgemeenAndersoortig materiaal

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Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration

Skeletal muscle alterations in patients with acute Covid-19 and post-acute sequelae of Covid-19

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