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N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2

YA Wang (Onderzoeker); P. Plastina (Onderzoeker); Jean-Paul Vincken (Onderzoeker); Renate Jansen (Onderzoeker); Michiel Balvers (Onderzoeker); Jean Paul ten Klooster (Lid Lectoraat); Harry Gruppen (Onderzoeker); Renger Witkamp (Onderzoeker); Jocelijn Meijerink (Onderzoeker)

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.6b00298 From teh publisher: "Several studies indicate that the n-3 long-chain polyunsaturated fatty acid docosahexaenoic acid (DHA) contributes to an attenuated inflammatory status in the development of neurodegenerative disorders, such as Alzheimer’s …

2017GezondheidArtikel

The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models

Marlotte M. Vonk (Onderzoeker); Laura Wagenaar (Onderzoeker); Raymond Pieters (Lector); Léon M.J. Knippels (Onderzoeker); L.E.M. Willemsen (Onderzoeker); J.J. Smit (Onderzoeker); BCAM van Esch (Onderzoeker); J. Garssen (Onderzoeker)

From Pubmed: " BACKGROUND: Antigen-specific immunotherapy (AIT) is a promising therapeutic approach for both cow's milk allergy (CMA) and peanut allergy (PNA), but needs optimization in terms of efficacy and safety. AIM: Compare oral immunotherapy (OIT) and subcutaneous immunotherapy (SCIT) in …

2017GezondheidArtikel

Gas sensing performance at room temperature of nanogap interdigitated electrodes for detection of acetone at low concentration

Q. Nguyen Minh (Onderzoeker); H.D. Tong (Onderzoeker); A. Kuijk (Onderzoeker); Franc van der Bent (Lid Lectoraat); P. Beekman (Onderzoeker); C.J.M. van Rijn (Onderzoeker)

From the article: "A facile approach for the fabrication of large-scale interdigitated nanogap electrodes (nanogap IDEs) with a controllable gap was demonstrated with conventional micro-fabrication technology to develop chemocapacitors for gas sensing applications. In this work, interdigitated nanogap …

2017TechniekArtikel

Using R in Life Sciences

Marc Teunis (Lid Lectoraat)

Gebruikt bij post-bachelorcursus Using R for Data Analysis: "... verdiep je je in de programmeertaal R. Dit is een programmeertaal die reproduceerbaarheid van onderzoek en data-analyse verhoogt. R wordt tegenwoordig breed gebruikt binnen verschillende takken van de wetenschap en daarnaast door grote …

2017GezondheidLezing

Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model

Marlotte M. Vonk (Onderzoeker); Mara A.P. Diks (Onderzoeker); Laura Wagenaar (Onderzoeker); J.J. Smit (Onderzoeker); Raymond Pieters (Lector); Johan Garssen (Onderzoeker); Betty C.A.M. van Esch (Onderzoeker); Léon M.J. Knippels (Onderzoeker)

From teh UU repository: "Background: Oral immunotherapy (OIT) is a promising therapeutic approach to treat food allergic patients. However, there are some concerns regarding its safety and long-term efficacy. The use of non-digestible oligosaccharides might improve OIT efficacy since they are known to …

2017GezondheidArtikel

Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

Raymond Pieters (Lector)

From the publisher: "Background: The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the …

2017GezondheidArtikel

Rapid chemoenzymatic route to glutamate transporter inhibitor l -TFB-TBOA and related amino acids

Fu, Haigen; Younes, Sabry H H; Saifuddin, Mohammad; Tepper, Pieter G; Zhang, Jielin; Keller, Erik; Heeres, André (Biobased Ingredients And Materials); Szymanski, Wiktor; Poelarends, Gerrit J

The complex amino acid (l-threo)-3-[3-[4-(trifluoromethyl)benzoylamino]benzyloxy]aspartate (l-TFB-TBOA) and its derivatives are privileged compounds for studying the roles of excitatory amino acid transporters (EAATs) in regulation of glutamatergic neurotransmission, animal behavior, and in the pathogenesis …

2017AlgemeenArtikel

Chromatographic behavior of anthocyanins on a C10CN stationary phase

Deineka, V.I.; Kulchenko, Yaroslava; University, Belgorod

The selectivity of the separation of some anthocyanins on Diasphere-11-C10CN stationary phase (phase I) is compared with the traditional reversed Symmetry C18 phase (phase II). It is found that, in contrast to phase II, phase I is effective in the separation of isomeric pairs of anthocyanins of 6-hydroxycyanidin- …

2017AlgemeenArtikel

Synthesis of C-1 Fluorinated Methyl Deoxythymidine-α-diphosphate-β-L-rhamnose Analogues as Inhibitors of Nucleotidylyl- and Rhamnosyltransferases.

Sherany Winter (Student)

Het is bekend dat bacteriën resistent worden tegen recent gebruikte antibiotica, dit resulteert in een vraag naar nieuwe medicijnen. Rhamnose is een 6-deoxy-L-suiker en vormt een belangrijk onderdeel van de bacteriële celwand. De biosynthese van deze suiker vindt alleen op natuurlijke wijze in bacteriën …

2016-11-25TechniekBachelor

Method development for the chiral separation of amino acids through micellar electrokinetic chromatography and inline derivatization with 9-fluoroenylmethyl chloroformate

Bennie Klomp (Student)

Aminozuren vormen de bouwstenen voor eiwitten en het is algemeen bekend dat deze een belangrijke functie hebben in vele biologische functies. Er is daarom veel belang bij de mogelijkheid om aminozuren snel en efficiënt te kunnen analyseren. De meeste amino zuren hebben een chiraal centrum en daardoor …

2016-11-25TechniekBachelor

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