Accurate assessment of TP53 gene status in sporadic tumors and in the germline of individuals at high risk of cancer due to Li–Fraumeni Syndrome (LFS) has important clinical implications for diagnosis, surveillance, and therapy. Genomic data from more than 20,000 cancer genomes provide a wealth of information …

Purpose: We investigated the effects of threat and trait anxiety on state anxiety and how that affects police officers’ actions during an arrest. Most experiments on police performance under anxiety test the performance of one particular skill. Yet, police work often involves concerted use of a combination …

Abstract: Hypertension is both a health problem and a financial one globally. It affects nearly 30 % of the general population. Elderly people, aged ≥65 years, are a special group of hypertensive patients. In this group, the overall prevalence of the disease reaches 60 %, rising to 70 % in those aged …

The aim of the present investigation was to evaluate the effect of visual feedback on rating voice quality severity level and the reliability of voice quality judgment by inexperienced listeners. For this purpose two training programs were created, each lasting 2 hours. In total 37 undergraduate speech–language …

Background: A pragmatic, stepped wedge trial design can be an appealing design to evaluate complex interventions in real-life settings. However, there are certain pitfalls that need to be considered. This paper reports on the experiences and lessons learned from the conduct of a cluster randomized, …

PURPOSE: As a first step to formulate a practical definition for movement quality (MQ), this study aims to explore how Dutch allied health care professionals (AHCPs) describe MQ of daily life activities in patients with low back pain (LBP). METHODS: In this qualitative cross-sectional digital survey …

The collapse of the Corporate Commercial Bank in 2014 is the biggest financial fraud case that occurred in Bulgaria since it joined the European Union. The prosecutors’ indictment defines it as a pyramid scheme case. It had a great impact on Bulgarian economy and politics, as its measurable impairment …

Over the past decades, Inconel 718 and titanium 6Al4V have established their roles as prefered material in the gas turbine industry. Production of complex parts with these alloys using conventional production however is time consuming and expensive. With AM fabrication of metals developing fast, the …

Background: This systematic review aimed to describe non-conveyance in ambulance care from patient-safety and ambulance professional perspectives. The review specifically focussed at describing (1) ambulance non-conveyance rates, (2) characteristics of non-conveyed patients, (3) follow-up care after …

A legal department’s objective is to support an organization in reaching its objectives, by seizing legal opportunity whenever possible and identifying and mitigating legal risks intelligently. To do this effectively, a proactive and structured approach is essential. Although times are changing, many …